{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:08:54Z","timestamp":1791216534004,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222114"],"award-info":[{"award-number":["7222114"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81904131"],"award-info":[{"award-number":["81904131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205034"],"award-info":[{"award-number":["82205034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune\u2010mediated disorder with aquaporin 4\u2010immunoglobulin G (AQP4\u2010IgG) in most settings. Soluble programmed death\u20101 (sPD\u20101) and soluble programmed death ligand 1 (sPD\u2010L1) play key roles in immunomodulation. We aim to assess the association of sPD\u20101 and sPD\u2010L1 with cytokines and their clinical significance in AQP4\u2010IgG (+) NMOSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We measured plasma sPD\u20101, sPD\u2010L1, and 10 cytokines levels of 66 AQP4\u2010IgG (+) NMOSD patients, including 40 patients in attack (attack\u2010NMOSD) and 26 patients in remission (remission\u2010NMOSD) phases, and 28 healthy controls through ultrasensitive Simoa and SP\u2010X platform, respectively. We also performed &gt;2\u2009years (median) of follow\u2010up after testing and analyzed the relationship between the detection index and current and future clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Plasma sPD\u20101 level discriminated attack\u2010NMOSD from remission\u2010NMOSD (AUC\u2009=\u20090.692, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). sPD\u20101 and sPD\u2010L1 levels positively correlated with IL\u20106 (<jats:italic>r<\/jats:italic><jats:sub>sPD\u20101<\/jats:sub>\u2009=\u20090.313; <jats:italic>r<\/jats:italic><jats:sub>sPD\u2010L1<\/jats:sub>\u2009=\u20090.508), IFN\u2010\u03b3 (<jats:italic>r<\/jats:italic><jats:sub>sPD\u20101<\/jats:sub>\u2009=\u20090.331; <jats:italic>r<\/jats:italic><jats:sub>sPD\u2010L1<\/jats:sub>\u2009=\u20090.456), and TNF\u2010\u03b1 (<jats:italic>r<\/jats:italic><jats:sub>sPD\u20101<\/jats:sub>\u2009=\u20090.451; <jats:italic>r<\/jats:italic><jats:sub>sPD\u2010L1<\/jats:sub>\u2009=\u20090.531) expression, as well as clinical indicators, including the EDSS score (<jats:italic>r<\/jats:italic><jats:sub>sPD\u20101<\/jats:sub>\u2009=\u20090.331; <jats:italic>r<\/jats:italic><jats:sub>sPD\u2010L1<\/jats:sub>\u2009=\u20090.402), number of attacks (<jats:italic>r<\/jats:italic><jats:sub>sPD\u20101<\/jats:sub>\u2009=\u20090.431) and segments of spinal cord involvement (<jats:italic>r<\/jats:italic><jats:sub>sPD\u20101<\/jats:sub>\u2009=\u20090.462; <jats:italic>r<\/jats:italic><jats:sub>sPD\u2010L1<\/jats:sub>\u2009=\u20090.508). The risk of relapse within 2\u2009years after sampling was associated with higher sPD\u20101\/sPD\u2010L1 ratio in attack\u2010NMOSD (<jats:italic>p<\/jats:italic>\u2009=\u20090.022; Exp(B)\u2009=\u20091.589).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Plasma sPD\u20101 and sPD\u2010L1 levels reflected current disease severity and activity, and predicted future relapses in AQP4\u2010IgG (+) NMOSD, suggesting that they hold the potential to guide timely and targeted treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51964","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T06:14:33Z","timestamp":1702102473000},"page":"436-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of plasma <scp>sPD<\/scp>\u20101 and <scp>sPD\u2010L1<\/scp> with disease status and future relapse in <scp>AQP4\u2010IgG<\/scp> (+) <scp>NMOSD<\/scp>"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7931-4288","authenticated-orcid":false,"given":"Jia","family":"Liu","sequence":"first","affiliation":[{"name":"Institute for Brain Disorders Beijing University of Chinese Medicine  Beijing China"},{"name":"Department of Neurology, Dongzhimen Hospital Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanbo","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang China"},{"name":"Key Laboratory of Neurology (Hebei Medical University) Ministry of Education  Shijiazhuang China"},{"name":"Neurological Laboratory of Hebei Province  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Institute for Brain Disorders Beijing University of Chinese Medicine  Beijing China"},{"name":"Department of Neurology, Dongzhimen Hospital Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang China"},{"name":"Key Laboratory of Neurology (Hebei Medical University) Ministry of Education  Shijiazhuang China"},{"name":"Neurological Laboratory of Hebei Province  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang China"},{"name":"Key Laboratory of Neurology (Hebei Medical University) Ministry of Education  Shijiazhuang China"},{"name":"Neurological Laboratory of Hebei Province  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5857"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-321988"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02249-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000841"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2021.1884223"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00568-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.746959"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02495-7"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102702"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20514"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/247637"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu1052oa"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1614683"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27500"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80089-8"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.10.006"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.05.006"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13123034"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192704"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12884"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40164"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50479-4"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2016.02.004"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.827921"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000605"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-018-2282-1"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21729"},{"issue":"2","key":"e_1_2_11_30_1","first-page":"116","article-title":"Serum soluble programmed cell death protein 1 could predict the current activity and severity of antineutrophil cytoplasmic antibody\u2010associated vasculitis: a monocentric prospective study","volume":"37","author":"Yoon T","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70133-3"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2017.1282821"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.06.035"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.853891"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.06.009"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.11.011"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2020.151959"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3248-y"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001135"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515598021"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3342-3"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.51964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T18:31:04Z","timestamp":1707849064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/acn3.51964"],"URL":"https:\/\/doi.org\/10.1002\/acn3.51964","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,8]]},"assertion":[{"value":"2023-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}