{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:20:42Z","timestamp":1789852842288,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical outcomes and relapse rates in neurosarcoidosis patients administered infliximab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted using the MEDLINE, EMBASE, SCOPUS, and Cochrane Library databases. The search included studies from their inception to March 2023. We included case\u2010series studies with at least 10 neurosarcoidosis patients undergoing any treatment type. Studies were also required to report at least one of the following outcomes: response rate, overall survival rate, or relapse rate. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines. A random\u2010effects model facilitated the analysis of proportional treatment outcomes. Study quality was evaluated using the modified Newcastle\u2013Ottawa quality assessment scale, while a funnel plot helped detect any publication bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven studies comprising 237 patients with neurosarcoidosis were included in the analysis. Of these patients, 184 (77.6%) received treatment with infliximab. The pooled proportion of patients showing clinical improvement after infliximab treatment was 0.74 (95% CI 0.64\u20130.84,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200949.73%). Relapse rates, derived from four studies, stood at 0.38 (95% CI 0.22\u20130.55,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200956.92%). Most studies reported successful tapering or cessation of corticosteroid dosage in patients receiving infliximab. Adverse effects were reported in 52 (29.4%) patients, of which 39 out of 54 events (72.2%) were linked to infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Infliximab demonstrated potential improvement in clinical outcomes for patients with refractory neurosarcoidosis and showed potential for reducing the dosage of concurrent corticosteroids. However, a degree of relapse was observed, with infections being the primary concern for adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.51968","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T01:39:46Z","timestamp":1702431586000},"page":"466-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Infliximab in neurosarcoidosis: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Siwakorn","family":"Chaiyanarm","sequence":"first","affiliation":[{"name":"Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok 10700 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piraya","family":"Satiraphan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok 10700 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