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Slow\u2010wave sleep, also known as deep non\u2010rapid eye movement (DNREM) sleep, was objectively assessed using the Verily Study Watch. Motor function was assessed using the Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale Part III score, Hoehn and Yahr stage, freezing of gait, motor fluctuations, and dyskinesia severity. Comprehensive assessments were conducted on nonmotor symptoms, including depression, anxiety, global cognitive function, and autonomic dysfunction. Statistical analyses involved repeated\u2010measures analysis of variance and linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 102 patients with PD were included in the study, with a median follow\u2010up duration of 3.4\u2009years. In the long DNREM sleep duration group (<jats:italic>n<\/jats:italic>\u2009=\u200955), better motor function (DNREM \u00d7 time interaction: <jats:italic>F<\/jats:italic><jats:sub><jats:italic>(1,100)<\/jats:italic><\/jats:sub>\u2009=\u20094.866, <jats:italic>p<\/jats:italic>\u2009=\u20090.030), less severe sexual dysfunction (<jats:italic>p<\/jats:italic>\u2009=\u20090.026), and improved activities of daily living (<jats:italic>p<\/jats:italic>\u2009=\u20090.033) were observed at the last follow\u2010up visit compared with the short DNREM sleep duration group (<jats:italic>n<\/jats:italic>\u2009=\u200947). Reduced DNREM sleep duration is a risk factor for motor progression (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.251, <jats:italic>p<\/jats:italic>\u2009=\u20090.021; 95% confidence interval\u2009=\u2009\u22120.465 to \u22120.038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The findings suggest an association between longer DNREM sleep duration and slower motor and nonmotor progression in patients with PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51975","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T11:27:48Z","timestamp":1702553268000},"page":"554-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Correlation of slow\u2010wave sleep with motor and nonmotor progression in Parkinson's disease"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-1044","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University  Beijing 100191 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