{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T13:59:11Z","timestamp":1747144751975,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH237","ZR2021QH125"],"award-info":[{"award-number":["ZR2021MH237","ZR2021QH125"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the value of magnetic resonance imaging (MRI) grading scores based on lumbosacral muscle denervation edema in predicting the course of Guillain\u2013Barr\u00e9 syndrome (GBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected data from 354 GBS patients and developed MRI grading criteria (5\u2010point scale) based on the transverse area and longitudinal length of lumbosacral edema. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with GBS prognosis among 12 demographic and radiological features. Clinical models and clinical\u2010MRI models were separately trained and validated by data from Institution 1. External test was performed using data from Institution 2. Differences between the models were assessed using the z\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four clinical factors (sex, albumin cytological dissociation in cerebrospinal fluid, medical research council [MRC] sum score at admission, and MRC sum score at discharge [odds ratio, 0.24\u20135.15; all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001]) and MRI grading scores (odds ratio, 2.44; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) are independent prognostic factors for GBS patients. The shallow neural network achieved the best prognostic performance both clinical model (accuracy of external test cohort, 83.96%) and clinical\u2010MRI model (accuracy of external test cohort, 90.56%). A significant difference between clinical and clinical\u2010MRI model was also found (clinical model vs. clinical\u2010MRI model, area under the receiver operating curve, 0.84 (95% CI: [0.71, 0.91]) vs. 0.97 (95% CI: [0.86, 0.99]), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The MRI grading scores for muscle denervation edema may serve as a potential prognostic risk factor for GBS. Furthermore, they significantly improve the prognostic performance of standalone clinical model in predicting GBS prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51984","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T08:18:56Z","timestamp":1703924336000},"page":"641-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radiologic grading scores enhance clinical model's prognostic ability for <scp>Guillain\u2013Barr\u00e9<\/scp> syndrome"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4677-4442","authenticated-orcid":false,"given":"Qiang","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifeng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiubin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health, Cheeloo College of Medicine, Shandong University  Jinan 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