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Moreover, the whole\u2010connectome showed greater node degree (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), while sensorimotor cortices resulted isolated in <jats:italic>C9orf72<\/jats:italic>+.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our results suggest a crucial involvement of extra\u2010motor functions in ALS spectrum disease. In particular, alterations of the visual cortex may have a pathogenic role in <jats:italic>C9orf72\u2010related<\/jats:italic> ALS. The prominent feature of these patients would be increased visual system connectivity with the networks responsible of the functional balance between internal and external attention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51989","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T05:50:05Z","timestamp":1705557005000},"page":"686-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Resting\u2010state fMRI functional connectome of <i>C9orf72<\/i> mutation status"],"prefix":"10.1002","volume":"11","author":[{"given":"Mario","family":"Stanziano","sequence":"first","affiliation":[{"name":"Neuroradiology Unit Foundation IRCCS Neurological Institute Carlo Besta  Milan Italy"},{"name":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience University of Turin  Turin 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