{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:41:45Z","timestamp":1780515705207,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to investigate the prognostic factors associated with clinical outcomes in CV2\/Collapsin response\u2010mediator protein 5 (CRMP5)\u2010IgG paraneoplastic neurologic disorders (PND).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study of patients with CV2\/CRMP5\u2010IgG PND evaluated between 2002\u20132022. We examined the association of clinical variables (including age, clinical phenotype [autoimmune encephalopathy, myelopathy, polyneuropathy\/radiculopathy, MG, cerebellar ataxia, chorea, optic neuropathy], cancer) with three clinical outcomes (wheelchair dependence, modified Rankin Scale [mRS], mortality) using univariate logistic regression and Cox proportional hazards modeling. Kaplan\u2013Meier estimates were used to determine the probability of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients (56% female) with CV2\/CRMP5\u2010IgG PND were identified with a median follow\u2010up of 54\u2009months (IQR\u2009=\u200911\u2013102). An underlying tumor was identified in 15 patients (56%) including small cell lung cancer (SCLC) (8, [53%]), thymoma (4, [27%]), and other histologies (3, [20%]). At last follow\u2010up, 10 patients (37%) needed a wheelchair for mobility and this outcome was associated with myelopathy (HR\u2009=\u20097.57, 95% CI\u2009=\u20091.87\u201330.64, <jats:italic>P<\/jats:italic>\u2009=\u20090.005). Moderate\u2013severe mRS\u2009=\u20093\u20135 was associated with CNS involvement (encephalopathy, myelopathy, or cerebellar ataxia) (OR\u2009=\u20097.00, 95% CI\u2009=\u20091.18\u201341.36, <jats:italic>P<\/jats:italic>\u2009=\u20090.032). The probability of survival 4\u2009years after symptom onset was 66%. Among cancer subtypes, SCLC (HR\u2009=\u200918.18, 95% CI\u2009=\u20093.55\u201393.04, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was significantly associated with mortality, while thymoma was not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In this retrospective longitudinal study of CV2\/CRMP5\u2010IgG PND, patients with CNS involvement, particularly myelopathy, had higher probability of disability. SCLC was the main determinant of survival in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.51991","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T11:45:30Z","timestamp":1705923930000},"page":"710-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predicting disability and mortality in CV2\/CRMP5\u2010IgG associated paraneoplastic neurologic disorders"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5633-4961","authenticated-orcid":false,"given":"Sanem P.","family":"Uysal","sequence":"first","affiliation":[{"name":"Department of Neurology Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4930-2168","authenticated-orcid":false,"given":"Yadi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Lerner Research Institute, Cleveland Clinic  Cleveland Ohio USA"},{"name":"Center for Outcomes Research &amp; Evaluation Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Lerner Research Institute, Cleveland Clinic  Cleveland Ohio USA"},{"name":"Center for Outcomes Research &amp; Evaluation Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Milinovich","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Lerner Research Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"Abbatemarco","sequence":"additional","affiliation":[{"name":"Mellen Center for Multiple Sclerosis Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Mellen Center for Multiple Sclerosis Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon S.","family":"Conway","sequence":"additional","affiliation":[{"name":"Mellen Center for Multiple Sclerosis Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ontaneda","sequence":"additional","affiliation":[{"name":"Mellen Center for Multiple Sclerosis Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Morren","sequence":"additional","affiliation":[{"name":"Neuromuscular Center Neurological Institute, Cleveland Clinic  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