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While our previous studies demonstrated that estrogen was partly responsible for this sexually dimorphic visual impairment, herein we elucidate the underlying mechanism. In contrast to their male counterparts, female <jats:italic>Nf1<\/jats:italic><jats:sup>OPG<\/jats:sup> mice have increased expression of glial interleukin\u20101\u03b2 (IL\u20101\u03b2), which is neurotoxic to RGCs <jats:italic>in vitro<\/jats:italic>. Importantly, both IL\u20101\u03b2 neutralization and leuprolide\u2010mediated estrogen suppression decrease IL\u20101\u03b2 expression and ameliorate RGC dysfunction, providing preclinical proof\u2010of\u2010concept evidence supporting novel neuroprotective strategies for NF1\u2010OPG\u2010induced vision loss.<\/jats:p>","DOI":"10.1002\/acn3.51995","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T06:50:01Z","timestamp":1705474201000},"page":"812-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Estrogen\u2010induced glial <scp>IL<\/scp>\u20101\u03b2 mediates extrinsic retinal ganglion cell vulnerability in murine <i>Nf1<\/i> optic glioma"],"prefix":"10.1002","volume":"11","author":[{"given":"Yunshuo","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri 63110 USA"},{"name":"Department 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