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From 60 patients, 85% (51 out of 60) showed one abnormal score across QoL assessments and 11 multimodal validated questionnaires. Compared to the premorbid state, QoL significantly deteriorated (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and, at a median of 41\u2009months, fatigue was its most important predictor (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.025). In total, 51% (26 out of 51) of carers reported significant burden. An abbreviated five\u2010item battery explained most variance in QoL. Wide\u2010ranging impacts post\u2010LGI1\u2010Ab\u2010E include decreased QoL and high caregiver strain. We identify a rapid method to capture QoL in routine clinic or clinical trial settings.\n                  <\/jats:p>","DOI":"10.1002\/acn3.52006","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:58:12Z","timestamp":1706835492000},"page":"1053-1058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Fatigue predicts quality of life after leucine\u2010rich glioma\u2010inactivated 1\u2010antibody encephalitis"],"prefix":"10.1002","volume":"11","author":[{"given":"Sophie N. 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Research University of Southern Denmark  Odense DK\u20105000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masud","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology University of Oxford  Oxford UK"},{"name":"Nuffield Department of Clinical Neurosciences  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7667-9748","authenticated-orcid":false,"given":"Sarosh R.","family":"Irani","sequence":"additional","affiliation":[{"name":"Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences  Oxford UK"},{"name":"Department of Neurology Oxford University Hospitals NHS Foundation Trust  Oxford UK"},{"name":"Departments of Neurology and Neurosciences Mayo Clinic  Jacksonville Florida 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