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We extended and validated the trial\u2010ready quantitative motor assessment battery \u201cQ\u2010Motor\u201d for upper limb movements with clinician\u2010reported, patient\u2010focused, and performance outcomes of ataxia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Exploratory single\u2010center cross\u2010sectional assessment in 94 subjects (46 cross\u2010genotype ataxia patients; 48 matched controls), comprising five tasks measured by force transducer and\/or position field: Finger Tapping, diadochokinesia, grip\u2010lift, and\u2014as novel implementations\u2014Spiral Drawing, and Target Reaching. Digital\u2010motor measures were selected if they discriminated from controls (AUC\u2009&gt;0.7) and correlated\u2014with at least one strong correlation (rho \u22650.6)\u2014to the Scale for the Assessment and Rating of Ataxia (SARA), activities of daily living (FARS\u2010ADL), and the Nine\u2010Hole Peg Test (9HPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six movement features with 69 measures met selection criteria, including\n                      <jats:italic>speed<\/jats:italic>\n                      and\n                      <jats:italic>variability<\/jats:italic>\n                      in all tasks,\n                      <jats:italic>stability<\/jats:italic>\n                      in grip\u2010lift, and\n                      <jats:italic>efficiency<\/jats:italic>\n                      in Target Reaching. The novel drawing\/reaching tasks best captured impairment in dexterity (|rho\n                      <jats:sub>9HPT<\/jats:sub>\n                      | \u22640.81) and FARS\u2010ADL upper limb items (|rho\n                      <jats:sub>ADLul<\/jats:sub>\n                      | \u22640.64), particularly by kinematic analysis of\n                      <jats:italic>smoothness (SPARC).<\/jats:italic>\n                      Target\n                      <jats:italic>hit rate<\/jats:italic>\n                      , a composite of\n                      <jats:italic>speed<\/jats:italic>\n                      and\n                      <jats:italic>endpoint precision<\/jats:italic>\n                      , almost perfectly discriminated ataxia and controls (AUC: 0.97). Selected measures in all tasks discriminated between mild, moderate, and severe impairment (SARA upper limb composite: 0\u20132\/&gt;2\u20134\/&gt;4\u20136) and correlated with severity in the trial\u2010relevant mild ataxia stage (SARA \u226410,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Q\u2010Motor assessment captures multiple features of impaired upper limb movements in degenerative ataxia. Validation with key clinical outcome domains provides the basis for evaluation in longitudinal studies and clinical trial settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.52024","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:42:35Z","timestamp":1712623355000},"page":"1097-1109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Multifeature quantitative motor assessment of upper limb ataxia including drawing and reaching"],"prefix":"10.1002","volume":"11","author":[{"given":"Dominik","family":"Hermle","sequence":"first","affiliation":[{"name":"Division Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology University of T\u00fcbingen  T\u00fcbingen 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Department of Neurology Heidelberg University Hospital  Heidelberg Germany"},{"name":"Department of Neurodegenerative Diseases Center of Neurology and Hertie Institute for Clinical Brain Research, University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Reilmann","sequence":"additional","affiliation":[{"name":"George\u2010Huntington\u2010Institute  M\u00fcnster Germany"},{"name":"Department of Neurodegenerative Diseases Center of Neurology and Hertie Institute for Clinical Brain Research, University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Department of Clinical Radiology University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"Division Translational Genomics of Neurodegenerative Diseases, 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