{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:06:31Z","timestamp":1788959191534,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amyloid\u2010related imaging abnormalities, were originally described by dementia care experts. The wider use of aducanumab and now lecanemab warrant broader understanding by the health care provider continuum. The optimal care approach for patients with Alzheimer's dementia, treated with amyloid\u2010targeted therapy, includes proper clinical diagnosis, complication surveillance, specific imaging protocols, expert specialty consultation, integrated treatment strategies, and proper facility system planning. Improved awareness and understanding of amyloid\u2010modifying therapy, both benefits and potential complications, among the health care provider continuum is paramount to the success of complex care programs. Specifically, recognition of treatment high risk, high benefit groups, and the interface of concurrent antiplatelet and anticoagulation. This integrated acute, specialty, and primary care approach should improve patient care quality and outcome.<\/jats:p>","DOI":"10.1002\/acn3.52042","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T04:59:16Z","timestamp":1719550756000},"page":"1669-1680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Amyloid\u2010related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid\u2010modifying therapy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6017-4203","authenticated-orcid":false,"given":"Rade B.","family":"Vukmir","sequence":"first","affiliation":[{"name":"Emergency Medicine Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c67808"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705971"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4161"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12377"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2305032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2351"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16059949"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.53347\/rID\u2010147243"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.37549\/ar1383"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2014.15.3.455"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.53347\/rID:46082"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.53347\/rID:25666"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.5.742"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.15.1823"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000050462.52753.B2"},{"issue":"1","key":"e_1_2_7_20_1","first-page":"88","article-title":"Brain microhemorrhages detected on T2*\u2010weighted gradient\u2010echo MR images","volume":"24","author":"Tsushima Y","year":"2003","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000133341.74387.96"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012778"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000816"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3174\/anjr.A3500"},{"key":"e_1_2_7_25_1","volume-title":"Alzheimer's Association International Conference (AAIC) Abstract 82916","author":"Abushakra S","year":"2022"},{"key":"e_1_2_7_26_1","article-title":"High prevalence of CAA\u2010related lesions in APOE e4\/4 homozygotes with early Alzheimer disease","author":"Ciccone I","year":"2023","journal-title":"Neurol Liv"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160216"},{"key":"e_1_2_7_28_1","unstructured":"Aduhelm Highlights of Prescribing Information. Accessed February 26 2023.https:\/\/www.aduhelm.com\/"},{"issue":"8","key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.14283\/jpad.2022.30","article-title":"Two randomized phase 3 studies of aducanumab in early Alzheimer's disease","volume":"2022","author":"Budd Haeberlein S","year":"2022","journal-title":"J Prev Alzheimers Dis"},{"key":"e_1_2_7_30_1","unstructured":"Leqembi Highlights of Prescribing Information.2024Accessed February 26 2023.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/761269s000lbl.pdf"},{"key":"e_1_2_7_31_1","unstructured":"Biogen to realign resources for Alzheimer's disease franchise. News Release2024."},{"key":"e_1_2_7_32_1","unstructured":"FDA News Release.FDA converts Alzheimer's disease treatment to traditional approval.2023."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13128"},{"issue":"1","key":"e_1_2_7_35_1","article-title":"Symptomatic amyloid related imaging abnormalities in an APOE 4\/4 patient treated with aducanumab","volume":"12","author":"VandeVrede L","year":"2020","journal-title":"Alzheimer's & Dement"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304430"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.862369"},{"key":"e_1_2_7_38_1","article-title":"Abstract Number\u2010224: Stroke mimic\u2014patient with symptomatic amyloid\u2010related imaging abnormalities presenting with stroke\u2010like symptoms","volume":"3","author":"Kmeid M","year":"2023","journal-title":"Stroke"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00152"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.41"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7586"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.14283\/iPad.2022.21"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1782"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000637\u20100"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043933\u20105"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010200610"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2215148"},{"key":"e_1_2_7_48_1","unstructured":"Leqembi Highlights of Prescribing Information. Accessed July 9 2023.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/761269s001lbl.pdf"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941875211408731"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.069542"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.52042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acn3.52042","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.52042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:01:04Z","timestamp":1777730464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.52042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/acn3.52042"],"URL":"https:\/\/doi.org\/10.1002\/acn3.52042","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,28]]},"assertion":[{"value":"2024-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}