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We present a case of a patient on glatiramer acetate for many years (initially Copaxone then Glatopa) who developed Nicolau syndrome, the second reported case after generic glatiramer acetate. All reported cases of Nicolau syndrome after glatiramer acetate are reviewed. The case highlights the importance of prompt recognition of this skin reaction by neurologists and raises awareness of the risks of skin reactions even in low\u2010risk injectable DMTs.<\/jats:p>","DOI":"10.1002\/acn3.52044","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T11:17:09Z","timestamp":1710415029000},"page":"1080-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nicolau syndrome following glatiramer acetate for multiple sclerosis: Case and review of reports"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-7006","authenticated-orcid":false,"given":"Methma","family":"Udawatta","sequence":"first","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts 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