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Pathogenic variants in <jats:italic>ARX<\/jats:italic> cause a pleomorphic syndrome that includes infantile epilepsy with a variety of movement disorders ranging from focal hand dystonia to generalized dystonia with frequent status dystonicus. In this report, we present three patients with severe movement disorders as part of <jats:italic>ARX<\/jats:italic>\u2010associated epilepsy\u2010dyskinesia syndrome, including a patient with a novel pathogenic missense variant (p.R371G). These cases illustrate diagnostic and management challenges of <jats:italic>ARX\u2010<\/jats:italic>related disorder and shed light on broader challenges concerning epilepsy\u2010dyskinesia syndromes.<\/jats:p>","DOI":"10.1002\/acn3.52055","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T04:40:44Z","timestamp":1715056844000},"page":"1643-1647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The spectrum of movement disorders in young children with <scp><i>ARX<\/i><\/scp>\u2010related <scp>epilepsy\u2010dyskinesia<\/scp> syndrome"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-591X","authenticated-orcid":false,"given":"Shyam K.","family":"Akula","sequence":"first","affiliation":[{"name":"Movement Disorders Program, Department of Neurology, Boston Children's Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of 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