{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:56:28Z","timestamp":1790268988631,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In light of clinical trials and disease\u2010modifying therapies, an early identification of patients at\u2010risk of developing Alzheimer's disease (AD) is crucial. Blood\u2010based biomarkers have shown promising results regarding the in vivo detection of the earliest neuropathological changes in AD. Herein, we investigated the ability of plasma p\u2010tau181 to act as a prescreening marker for amyloid positivity in a heterogeneous memory clinic\u2010based cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective cross\u2010sectional study, we included a total of 115 patients along the clinical AD continuum (mild cognitive impairment [MCI] due to AD, <jats:italic>n<\/jats:italic>\u2009=\u200962, probable AD dementia, <jats:italic>n<\/jats:italic>\u2009=\u200953). Based on their biomarker status, they were stratified into an amyloid\u2010positive (A\u03b2+, <jats:italic>n<\/jats:italic>\u2009=\u200988) or amyloid\u2010negative cohort (A\u03b2\u2212, <jats:italic>n<\/jats:italic>\u2009=\u200927). Plasma and CSF p\u2010tau181 concentrations were quantified using an ultrasensitive single\u2010molecule array (SIMOA\u00a9). Furthermore, age\u2010 and sex\u2010adjusted receiver operating characteristic (ROC) curves were calculated and the area under the curve (AUC) of each model was compared using DeLong's test for correlated AUC curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median (interquartile range [IQR]) concentration of plasma p\u2010tau181 was significantly higher in A\u03b2+\u2009patients (3.6\u2009pg\/mL [2.5\u20134.6]), compared with A\u03b2\u2212 patients (1.7\u2009pg\/mL [1.2\u20131.9], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Regarding the distinction between A\u03b2+ and A\u03b2\u2212 patients and the prediction of amyloid positivity, a high diagnostic accuracy for plasma p\u2010tau181 with an AUC of 0.89 (95% CI\u2009=\u20090.82\u20130.95) was calculated. Adding the risk factors, age and <jats:italic>APOE4,<\/jats:italic> to the model did not significantly improve its performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our findings demonstrate that plasma p\u2010tau181 could be a noninvasive and feasible prescreening marker for amyloid positivity in a heterogeneous clinical AD cohort and therefore help in identifying those who would benefit from more invasive assessment of amyloid pathology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52116","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T05:59:44Z","timestamp":1720159184000},"page":"1988-1998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Real\u2010world performance of plasma p\u2010tau181 in a heterogeneous memory clinic 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