{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:33:32Z","timestamp":1787168012900,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective was to determine the mean duration of diagnosis delay for patients with myasthenia gravis from five European countries and explore the impact of &gt;1\u2009year diagnosis delay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with myasthenia gravis (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009387) from Europe (France\/Germany\/Italy\/Spain\/United Kingdom) and their physicians participated in the Adelphi Real World Myasthenia Gravis Disease Specific Programme\u2122. Diagnosis delay (time from symptom onset to diagnosis) was calculated and characteristics described for patients experiencing &gt;1\u2009year and \u22641\u2009year diagnosis delay. Denominators varied according to outcome as missing data were not imputed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean (standard deviation) diagnosis delay was 363.1 (520.9) days, and 27.1% (105 out of 387) of patients experienced diagnosis delay &gt;1\u2009year. Among patients with &gt;1\u2009year and \u22641\u2009year diagnosis delay, respectively, 69.2% (72 out of 104) and 17.4% [45 out of 259] had initially received a different diagnosis (physician\u2010reported); 40.0% (42 out of 105) and 24.1% (68 out of 282) were Myasthenia Gravis Foundation of America class III at the time of the survey (physician\u2010reported); 72.4% (76 out of 105) and 61.3% (173 out of 282) had fatigue (subjective physician reporting from a pre\u2010selected list of symptoms); 30.5% (32 out of 105) and 17.4% (49 out of 282) had anxiety and 21.9% (23 out of 105) and 13.1% (37 out of 282) had depression (both subjective physician reporting from a pre\u2010selected list, Likert\u2010style); and mean (standard deviation) MG\u2010QoL\u201015r score was 14.4 (5.50) and 12.6 (7.84) (self\u2010reported by\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200943 and\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200974 patients, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>More than a quarter of patients with myasthenia gravis experienced diagnosis delay of &gt;1\u2009year. These patients had a different clinical profile with regards to severity, symptoms, comorbidities and MG\u2010QoL\u201015r score, compared with patients experiencing \u22641\u2009year diagnosis delay.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.52122","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:40:07Z","timestamp":1722559207000},"page":"2254-2267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The impact of diagnosis delay on European patients with generalised myasthenia gravis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1428-1072","authenticated-orcid":false,"given":"Elena","family":"Cort\u00e9s\u2010Vicente","sequence":"first","affiliation":[{"name":"Neuromuscular Diseases Unit, Department of Neurology Hospital de la Santa Creu I Sant Pau  Barcelona 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