{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:16:07Z","timestamp":1786976167556,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC2151\u2013390873048"],"award-info":[{"award-number":["EXC2151\u2013390873048"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Informative biomarkers are an urgent need in the management of amyotrophic lateral sclerosis. Serum cardiac troponin T is elevated in the majority of amyotrophic lateral sclerosis patients and increases with disease progression. We sought to establish the informative value of cardiac troponin T with regard to respiratory function, a major prognostic factor in amyotrophic lateral sclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective observation, we analyzed two independent hospital\u2010based cohorts (\n                      <jats:italic>d<\/jats:italic>\n                      \u2009=\u2009discovery cohort;\n                      <jats:italic>v<\/jats:italic>\n                      \u2009=\u2009validation cohort) regarding serum cardiac troponin T (\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>d<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u2009298;\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>v<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u200949), serum neurofilament light chain (\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>d<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u2009117;\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>v<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u200917), and respiratory tests (\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>d<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u200993;\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>v<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u200949).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum cardiac troponin T, in contrast to serum neurofilament levels, was associated with the respiratory domain of the revised amyotrophic lateral sclerosis functional rating scale and with pulmonary function parameters, namely forced vital capacity % (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and slow vital capacity % (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                    <jats:p>Serum cardiac troponin T reliably discriminated benchmarks of slow vital capacity &lt;80% (AUC 0.73, 95% CI 0.62\u20130.84) and &lt;50% (AUC 0.80, 95% CI 0.68\u20130.93), forced vital capacity &lt;80% (AUC 0.72, 95% CI 0.61\u20130.83) and &lt;50% (AUC 0.79, 95% CI 0.67\u20130.91).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Our findings position cardiac Troponin T as a valuable serum biomarker in amyotrophic lateral sclerosis, complementing neurofilaments and expanding the understanding of underlying physiological mechanisms. In clinical practice, serum cardiac troponin T can flag benchmarks of compromised respiratory function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.52126","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T03:14:55Z","timestamp":1719285295000},"page":"2063-2072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cardiac troponin T as a serum biomarker of respiratory impairment in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6925-8256","authenticated-orcid":false,"given":"Teresa","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Neuromuscular Diseases, Center for Neurology University Hospital Bonn  Bonn 53127 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Fabian","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases, Center for Neurology University Hospital Bonn  Bonn 53127 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Weinhold","sequence":"additional","affiliation":[{"name":"Department for Medical Biometry, Informatics and Epidemiology University Hospital Bonn  Bonn 53127 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz\u2010W.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Pulmology Neuk\u00f6lln Hospital  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Barakat","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases, Center for Neurology University Hospital Bonn  Bonn 53127 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-474X","authenticated-orcid":false,"given":"Sergio","family":"Castro\u2010Gomez","sequence":"additional","affiliation":[{"name":"Department of Parkinson, Sleep and Movement Disorders, Center for Neurology University Hospital Bonn  Bonn 53127 Germany"},{"name":"Institute of Physiology II University Hospital Bonn  Bonn 53115 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Grehl","sequence":"additional","affiliation":[{"name":"Department of Neurology Alfried \u2010 Krupp\u2010Hospital  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bernsen","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases, Center for Neurology University Hospital Bonn  Bonn 53127 Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn 53127 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-5662","authenticated-orcid":false,"given":"Patrick","family":"Weydt","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases, Center for Neurology University Hospital Bonn  Bonn 53127 Germany"},{"name":"Department of Parkinson, Sleep and Movement Disorders, Center for Neurology University Hospital Bonn  Bonn 53127 Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn 53127 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01272\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010023\u201000891\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15773"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001642"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164625"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab274"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2021.1939384"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.058489"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.027"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.070"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.13.74"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756286419857040"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(05)70326\u20104"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2018.1457058"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30089\u20109"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000148648.38313.64"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3339"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bc0141"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466\u2010023\u201000251\u2010x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760\u2010015\u20100596\u20108"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482960802566824"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.01.026"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12851"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress\u20102015.PA3730"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.938256"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760\u2010017\u20100855\u2010y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2012.696659"},{"issue":"7","key":"e_1_2_10_30_1","first-page":"615","article-title":"Amyotrophic lateral sclerosis (ALS), a novel rare cause of elevated plasma troponin T levels","volume":"57","author":"Lueder TGV","year":"2011","journal-title":"Clin Lab"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvasa.2014.12.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000955\u2010x"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.52126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T11:57:09Z","timestamp":1723895829000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.52126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/acn3.52126"],"URL":"https:\/\/doi.org\/10.1002\/acn3.52126","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"2024-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}