{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:19:48Z","timestamp":1787678388529,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014543","name":"Institute for Collaborative Biotechnologies","doi-asserted-by":"publisher","award":["W911NF\u201019\u20102\u20100026"],"award-info":[{"award-number":["W911NF\u201019\u20102\u20100026"]}],"id":[{"id":"10.13039\/100014543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["431549029\u2010SFB1451"],"award-info":[{"award-number":["431549029\u2010SFB1451"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The corticospinal tract (CST) is considered the most important motor output pathway comprising fibers from the primary motor cortex (M1) and various premotor areas. Damage to its descending fibers after stroke commonly leads to motor impairment. While premotor areas are thought to critically support motor recovery after stroke, the functional role of their corticospinal output for different aspects of post\u2010stroke motor control remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed the differential role of CST fibers originating from premotor areas and M1 in the control of basal (single\u2010joint muscle synergies and strength) and complex motor control (involving inter\u2010joint coordination and visuomotor integration) using a novel diffusion imaging approach in chronic stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While M1 sub\u2010tract anisotropy was positively correlated with basal and complex motor skills, anisotropy of PMd, PMv, and SMA sub\u2010tracts was exclusively associated with complex motor tasks. Interestingly, patients featuring persistent motor deficits showed an additional positive association between premotor sub\u2010tract integrity and basal motor control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>While descending M1 output seems to be a prerequisite for any form of upper limb movements, complex motor skills critically depend on output from premotor areas after stroke. The additional involvement of premotor tracts in basal motor control in patients with persistent deficits emphasizes their compensatory capacity in post\u2010stroke motor control. In summary, our findings highlight the pivotal role of descending corticospinal output from premotor areas for motor control after stroke, which thus serve as prime candidates for future interventions to amplify motor recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.52159","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T01:55:36Z","timestamp":1722218136000},"page":"2439-2449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Corticospinal premotor fibers facilitate complex motor control after stroke"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-7503","authenticated-orcid":false,"given":"Theresa","family":"Paul","sequence":"first","affiliation":[{"name":"Medical Faculty, University of Cologne, and Department of Neurology University Hospital Cologne  Cologne Germany"},{"name":"Institute of Neuroscience and Medicine Cognitive Neuroscience (INM\u20103), Research Centre Juelich  Juelich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cieslak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Hensel","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Cologne, and Department of Neurology University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie M.","family":"Wiemer","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Cologne, and Department of Neurology University Hospital Cologne  Cologne Germany"},{"name":"Institute of Neuroscience and Medicine Cognitive Neuroscience (INM\u20103), Research Centre Juelich  Juelich 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