{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:01:37Z","timestamp":1789563697764,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe patient clinical characteristics associated with matched oligoclonal bands (OCB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review at the University of Utah examined patients with matched OCB from 2015 to 2020. Clinical data, diagnosis, and outcomes were collected. Patients were classified with either multiple sclerosis (MS), other inflammatory neurologic disorder (other\u2010IND), or noninflammatory neurologic disorder (NIND).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 539 identified patients, 436 (53.4% female) were matched\u2010only, while 103 (43.7% female) were matched + unique. Patients with matched\u2010only bands were older (57.4\u2009\u00b1\u200916 vs. 52\u2009\u00b1\u200914.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and more likely to have a history of autoimmune disease (40.1% vs. 28.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.024) and\/or cancer (28.7% vs. 16.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.012). Patients with matched + unique bands were more likely to have CSF pleocytosis (52.4% vs. 25.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), high IgG index (52.2% vs. 7.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and an abnormal MRI (86.9% vs. 63.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). More than two\u2010thirds of matched\u2010only patients had NIND, while 33% and 41.7% of matched + unique patients had MS and other\u2010IND, respectively. Patients exhibiting matched\u2010only bands and a high IgG index demonstrated a significantly higher incidence of other\u2010IND compared to those with matched\u2010only bands and a normal IgG index (55.6% vs. 30.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.013). While Kaplan\u2013Meier survival curves demonstrated higher mortality in the matched\u2010only cohort compared to the matched + unique cohort (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), multivariable Cox regression analysis showed this difference was not statistically significant when adjusting for various factors. A history of cancer was the significant predictor of increased mortality risk (Hazard ratio\u2009=\u20093.147, 95% CI [2.196, 4.51]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Patients with matched only versus matched + unique OCB have distinct clinical profiles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52162","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T12:05:07Z","timestamp":1729598707000},"page":"2846-2854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Matched oligoclonal bands: Diagnostic utility and clinical characteristics"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0228-664X","authenticated-orcid":false,"given":"Yoji","family":"Hoshina","sequence":"first","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"Abbatemarco","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"},{"name":"Mellen Center for Multiple Sclerosis Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie J.","family":"Rodenbeck","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"},{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason T.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"},{"name":"Department of Neurosciences Evergreen Health  Kirkland WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Division, Department of Pediatrics University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Mateo","family":"Paz Soldan","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"},{"name":"George E. Wahlen Veterans Affairs Medical Center  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7788-6178","authenticated-orcid":false,"given":"John E.","family":"Greenlee","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"},{"name":"George E. Wahlen Veterans Affairs Medical Center  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"},{"name":"George E. Wahlen Veterans Affairs Medical Center  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa K.","family":"Peterson","sequence":"additional","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology  Salt Lake City Utah USA"},{"name":"Department of Pathology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Johnson","sequence":"additional","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology  Salt Lake City Utah USA"},{"name":"Department of Pathology University of Utah  Salt Lake City Utah USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alen","family":"Delic","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"},{"name":"George E. Wahlen Veterans Affairs Medical Center  Salt Lake City Utah USA"},{"name":"ARUP Institute for Clinical and Experimental Pathology  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Clardy","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"},{"name":"George E. 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