{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:04:32Z","timestamp":1791345872712,"version":"4.3.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2008339"],"award-info":[{"award-number":["GNT2008339"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021071","name":"Faculty of Medicine and Health, University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myelin oligodendrocyte glycoprotein antibody\u2010associated disease (MOGAD) is diagnosed by serum MOG\u2010immunoglobulin G (MOG\u2010IgG) in association with typical demyelination. 111\/1127 patients with paired CSF\/serum samples were seropositive for MOG\u2010IgG. Only 7\/1016 (0.7%) seronegative patients had CSF\u2010restricted MOG\u2010IgG. While 3\/7 patients had longitudinally extensive transverse myelitis, four had a confirmed alternate diagnosis (three multiple sclerosis, one CNS vasculitis). In a national referral setting, CSF\u2010restricted MOG\u2010IgG had a low sensitivity (2.63%, 95%CI 0.55\u20137.50%) and low positive predictive value (1.97%, 95%CI 0.45\u20138.13%). We strongly recommend serum as the preferred diagnostic biospecimen, and urge caution in the interpretation of CSF\u2010restricted MOG\u2010IgG in patients without clinico\u2010radiological features consistent with MOGAD.<\/jats:p>","DOI":"10.1002\/acn3.52163","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T02:43:37Z","timestamp":1722221017000},"page":"2514-2519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The clinical relevance of\n                    <scp>MOG<\/scp>\n                    antibody testing in cerebrospinal fluid"],"prefix":"10.1002","volume":"11","author":[{"given":"Molly","family":"Reynolds","sequence":"first","affiliation":[{"name":"Translational Neuroimmunology Group, Kids Neuroscience Centre, Faculty of Medicine and Health University of Sydney  Sydney Australia"},{"name":"Department of Neurology Concord Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Radiology Concord Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Brain Autoimmunity Group Kids Neuroscience Centre, Children's Hospital at Westmead  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Merheb","sequence":"additional","affiliation":[{"name":"Brain Autoimmunity Group Kids Neuroscience Centre, Children's Hospital at Westmead  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona X. 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