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The cerebral cortex is central for adapting the locomotion pattern to the environment and alterations of cortical network dynamics can lead to gait impairments. Gait problems are a common symptom with a still unclear pathophysiology and represent an unmet therapeutical need in Parkinson's disease. Little is known about the cortical network dynamics of locomotor control in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the cortical basis of parkinsonian gait by combining metabolic brain imaging with high\u2010density EEG recordings and kinematic measurements performed at rest and during unperturbed overground walking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found significant changes in functional connectivity between frontal, sensorimotor, and visuomotor cortical areas during walking as compared to resting. Specifically, hypokinetic gait was associated with poor information flow from the supplementary motor area (SMA) to precuneus and from calcarine to lingual gyrus, as well as high information flow from calcarine to cuneus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our findings support a role for visuomotor integration processes in PD\u2010related hypokinetic gait and suggest that reinforcing visual information may act as a compensatory strategy to allow SMA\u2010mediated feedforward locomotor control in PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52173","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T15:38:35Z","timestamp":1724686715000},"page":"2597-2608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cortical networks of parkinsonian gait: a metabolic and functional connectivity study"],"prefix":"10.1002","volume":"11","author":[{"given":"Franziska","family":"Pellegrini","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Center for Advanced Neuroimaging (BCAN)  Berlin Germany"},{"name":"Bernstein Center for Computational Neuroscience  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-0168","authenticated-orcid":false,"given":"Nicol\u00f3 G.","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of W\u00fcrzburg and The Julius Maximilian University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-6462","authenticated-orcid":false,"given":"Chiara","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of W\u00fcrzburg and The Julius Maximilian University of W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Parkinson Institute of Milan ASST G. 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