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A 22\u2010year\u2010old male presented with fatal and fulminant diffuse leptomeningitis. Next\u2010generation sequencing of plasma and cerebrospinal circulating tumour DNA revealed diffuse midline gliomas with <jats:italic>H3F3A<\/jats:italic> and <jats:italic>FGFR<\/jats:italic> mutations. Methylome analysis of meningeal tissue collected during autopsy confirmed the diagnosis. Liquid biopsy plays a crucial role in the diagnosis of diffuse midline gliomas, mainly those with exclusively leptomeningeal presentations.<\/jats:p>","DOI":"10.1002\/acn3.52180","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:41:19Z","timestamp":1729676479000},"page":"3037-3041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fulminant leptomeningeal disease diagnosed as comutant <i>H3F3A<\/i> and <i>FGFR<\/i> diffuse midline glioma"],"prefix":"10.1002","volume":"11","author":[{"given":"Larysa","family":"Benistant","sequence":"first","affiliation":[{"name":"Oncology Department Institut de Canc\u00e9rologie Strasbourg Europe  17 Avenue Albert Calmette Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Reita","sequence":"additional","affiliation":[{"name":"Molecular Biology Department University Hospital Strasbourg  1 Avenue 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