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Cerebrospinal fluid (CSF) biomarkers for AD were analyzed. Linear regression models related SCD to CSF AD biomarkers and follow\u2010up models assessed interactions of <jats:italic>SCD\u2009\u00d7\u2009cognitive status, sex, reading level<\/jats:italic>, and <jats:italic>education<\/jats:italic> on AD biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In main effect models, higher SCD was associated with more amyloidosis (<jats:italic>p<\/jats:italic>\u2010values &lt;0.004). SCD was not associated with tau, p\u2010tau, or neurofilament light (NFL) levels (<jats:italic>p\u2010<\/jats:italic>values &gt;0.38). SCD score interacted with cognitive status (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.02), sex (<jats:italic>p<\/jats:italic>\u2009=\u20090.03), and education (<jats:italic>p<\/jats:italic>\u2010values\u2009<jats:italic>&lt;<\/jats:italic>0.005) on amyloidosis. In stratified models, higher SCD was associated with more amyloid in cognitively unimpaired (<jats:italic>p<\/jats:italic>\u2010values\u2009&lt;0.003), men (<jats:italic>p<\/jats:italic>\u2009=\u20090.0003), and higher education. No <jats:italic>SCD score\u2009\u00d7\u2009reading\u2010level<\/jats:italic> interaction was found (<jats:italic>p<\/jats:italic>\u2010values &gt;0.51) though SCD related to amyloid markers in the higher reading\u2010level group (<jats:italic>p<\/jats:italic>\u2010values &lt;0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Higher SCD was associated with greater cerebral amyloid accumulation, one of the earliest pathological AD changes. SCD appears most useful in detecting early AD\u2010related brain changes prior to objective cognitive impairment, in men, and those with higher quantity and quality of education and highlight the importance of considering these factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52209","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T10:11:59Z","timestamp":1729678319000},"page":"2977-2986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cognitive status and demographics modify the association between subjective cognition and amyloid"],"prefix":"10.1002","volume":"11","author":[{"given":"Corey J.","family":"Bolton","sequence":"first","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee 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