{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:20:27Z","timestamp":1784852427523,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271903"],"award-info":[{"award-number":["82271903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To delineate the characteristics of stroke\u2010like episodes (SLEs) in patients with adult\u2010onset neuronal intranuclear inclusion disease (NIID) and to compare these characteristics with those of patients with MELAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three adult\u2010onset NIID patients who presented with acute or subacute brain disorders and 13 late\u2010onset MELAS patients were enrolled in the study. Patients with NIID were categorized into the SLEs group and the encephalopathy\u2010like episodes (ELEs) group according to the associated stroke\u2010like lesions (SLLs) findings. Clinical characteristics were compared between the SLEs group and the ELEs group among NIID patients and between NIID patients with SLEs and MELAS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven (47.8%) NIID patients who manifested acute or subacute brain disorders had detectable associated SLLs and were categorized into SLEs group. SLEs patients were more likely to report fever, headache, and seizures instead of sleep disorders than ELEs patients. Four (36.4%) NIID patients with SLEs absence of diagnostic or suggestive NIID imaging features. The clinical manifestations, laboratory test results, and neuroimaging and muscle biopsy histological features of NIID patients with SLEs majorly overlapped with those of late\u2010onset MELAS patients. Older age at the first SLE (OR [95% CI], 1.203 [1.045\u20131.384]), symptoms of movement disorders on admission (OR [95% CI], 9.625 [1.378\u201367.246]), and white matter hyperintensity in corpus callosum (OR [95% CI], 16.00 [1.542\u2013166.46]) associated with the NIID diagnosis in patients with SLEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>NIID patients with SLEs exhibit evident features of mitochondrial disorders. Interventions aimed at mitochondrial dysfunction might be a promising therapeutic approach for treating this disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52219","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T06:20:17Z","timestamp":1728109217000},"page":"3125-3136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stroke\u2010like episodes in patients with adult\u2010onset neuronal intranuclear inclusion disease and patients with late\u2010onset <scp>MELAS<\/scp>: A comparative study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-6984","authenticated-orcid":false,"given":"Yuzhi","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital, Capital Medical University  Beijing 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