{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:15:26Z","timestamp":1786976126426,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201023\u2010RHUS\u201006"],"award-info":[{"award-number":["ANR\u201023\u2010RHUS\u201006"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this neuropathological study, we investigated neuroinflammation surrounding recent and old cerebral microbleeds (CMBs) and cerebral microinfarcts (CMIs) in 18 cases of cerebral amyloid angiopathy (CAA). We used several serial stainings and immunolabellings to identify microvascular lesions, define their recent or old stage, and characterize neuroinflammatory response (scavenging activity and astrogliosis). We found that both CMBs and CMIs induce a neuroinflammatory response, which was more pronounced in old lesion than recent. Astrogliosis and scavenging activity were differentially prominent according to the ischemic\/hemorrhagic nature of the lesion. Our findings provide insights into the pathophysiology of microvascular injuries in CAA.<\/jats:p>","DOI":"10.1002\/acn3.52226","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T02:35:57Z","timestamp":1730774157000},"page":"3328-3332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Distinct neuroinflammatory patterns between cerebral microbleeds and microinfarcts in cerebral amyloid angiopathy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9772-5192","authenticated-orcid":false,"given":"Laurent","family":"Puy","sequence":"first","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  F\u201059000 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Barus","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  F\u201059000 Lille France"},{"name":"Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-2459","authenticated-orcid":false,"given":"Marco","family":"Pasi","sequence":"additional","affiliation":[{"name":"Department of Neurology Tours Regional University Hospital, Hospital Trousseau  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"P\u00e9trault","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  F\u201059000 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Deramecourt","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  F\u201059000 Lille France"},{"name":"Univ Lille, Lille Neuroscience &amp; Cognition (Inserm UMRS1172) Development and Plasticity of the Neuroendocrine Brain  Lille France"},{"name":"Department of Neuropathology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5697-6892","authenticated-orcid":false,"given":"Charlotte","family":"Cordonnier","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1172 \u2010 LilNCog \u2010 Lille Neuroscience &amp; Cognition  F\u201059000 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"B\u00e9r\u00e9zowski","sequence":"additional","affiliation":[{"name":"Univ. 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