{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:41:51Z","timestamp":1789512111502,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Poststroke aphasia (PSA) has a high prevalence and requires a long recovery period, severely impairing life and work. Its existing behavioral interventions, principally speech and language therapy, are limited by numerous factors. The aims of this study are to evaluate the efficacy and safety of DL\u20103\u2010N\u2010butylphthalein (NBP) and explore its mechanism in the treatment of ischemic PSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients hospitalized in the Second Hospital of Hebei Medical University in China were randomly administered NBP soft capsules or placebo orally for 6 months from July 1, 2021, to February 25, 2023. Language skills were assessed using the Western Aphasia Battery\u2010Aphasia Quotient (WAB\u2010AQ). We collected plasma samples and detected neurotransmitters by liquid chromatography\u2010mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 118 out of 124 patients were included in the outcome analysis. Compared with the control group, AQ values in the NBP group significantly improved at 6\u2009months (<jats:italic>U<\/jats:italic>\u2009=\u20091187.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). After eliminating baseline interference, NBP treatment was independently associated with the 6\u2010month AQ improvement [mean difference (MD) 0.106, 95% confidence interval (CI) 0.018, 0.195, <jats:italic>p<\/jats:italic>\u2009=\u20090.019]. We observed no statistically significant difference between the groups in abnormal liver function at 1\u2009month [relative risk (RR) 1.07, 95% CI 0.89, 1.28] and 6\u2009months [RR 0.99, 95% CI 0.86, 1.42]. Statistically significant differences were observed in tyrosine (<jats:italic>p<\/jats:italic>\u2009=\u20090.043) and 5\u2010hydroxytryptophan (<jats:italic>p<\/jats:italic>\u2009=\u20090.041) between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>NBP treatment might promote the recovery of WAB\u2010AQ in patients with ischemic PSA by increasing levels of monoamine neurotransmitters.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52238","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T10:44:18Z","timestamp":1732272258000},"page":"3300-3309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of <scp>DL<\/scp>\u20103\u2010N\u2010butylphthalide in the treatment of ischemic poststroke aphasia: A randomized clinical 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