{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:22:09Z","timestamp":1787862129004,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["5R01HD091492\u201005"],"award-info":[{"award-number":["5R01HD091492\u201005"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RO1HD091492"],"award-info":[{"award-number":["1RO1HD091492"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1F31HD111318\u201001"],"award-info":[{"award-number":["1F31HD111318\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this work was to evaluate if task\u2010specific training (TST) preceded by bilateral upper limb motor priming (BUMP) reduces upper limb impairment more than TST preceded by control priming ([CP], sham electrical stimulation) in people with chronic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010blind, randomized controlled trial, 76 adults with moderate to severe upper limb hemiparesis \u22656\u2009months post\u2010stroke were stratified by baseline impairment and randomized to receive either BUMP or CP prior to receiving the same TST protocol. Participants completed 30\u2009h of treatment in 15\u2009days over 6\u2009weeks. The primary outcome was change in Fugl\u2010Meyer upper extremity (FMUE) from baseline to 8\u2010week follow\u2010up. We also report clinically meaningful response rates defined as a change in FMUE score of 6 points or greater.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In response to treatment, both groups improved to a significant extent at follow\u2010up, exceeding the FMUE minimum clinically important difference. Those in BUMP and CP saw a mean change of 5.68 (SE 0.76, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 5.87 (SE 0.76, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) respectively. There was no significant difference between treatment arms (mean difference of \u22120.20 (95% CI\u2009=\u2009[\u22122.37, 1.97], SE\u2009=\u20091.08, <jats:italic>p<\/jats:italic>\u2009=\u20090.86)). A response of \u22656 points was observed in 46% in BUMP and 50% in CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>There was no beneficial effect of BUMP. The magnitude of change seen in both groups reflects the largest improvement achieved with just 22.5\u2009h of TST in this population, matching or out\u2010performing more invasive, time\u2010intensive, and costly interventions proposed in recent years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52271","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T16:24:27Z","timestamp":1734452667000},"page":"192-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Priming and task\u2010specific training for arm weakness post stroke: A randomized controlled trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-3845","authenticated-orcid":false,"given":"Erin C.","family":"King","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences Northwestern University Feinberg School of Medicine  Chicago Illinois 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