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The accuracy of \u03b1Syn SAA was 87.7% in skin, 67.4% in duodenum, and 80.0% in gastric biopsies, with significantly higher sensitivity in advanced PD (skin: 81.8%; gastric: 88.9%; duodenal 58.8%). Misfolded \u03b1Syn was detected with higher sensitivity in advanced PD across all matrices, likely reflecting the progression of \u03b1Syn pathology. The seeding activity was lower in the duodenal than in the gastric wall, indicating differences in \u03b1Syn burden.<\/jats:p>","DOI":"10.1002\/acn3.52282","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T17:39:31Z","timestamp":1734802771000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Alpha\u2010synuclein <scp>RT<\/scp>\u2010<scp>QuIC<\/scp> assay in gastroduodenal and skin biopsies of Parkinson disease patients"],"prefix":"10.1002","volume":"12","author":[{"given":"Aron","family":"Emmi","sequence":"first","affiliation":[{"name":"Parkinson and Movement Disorders Unit, Department of Neuroscience, Centre for Rare Neurological Diseases (ERN\u2010RND) University of Padova  Padova Italy"},{"name":"Center for Neurodegenerative Disease Research (CESNE) University of Padova  Padova Italy"},{"name":"Department of Neuroscience, Institute of Human Anatomy 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