{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:38:52Z","timestamp":1780544332750,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014895","name":"Open Philanthropy Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Evidence for an association between psoriasis and dementia is limited and conflicting. We aimed to investigate the association using large and representative population\u2010based data and describe risk by dementia subtype and over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared dementia risk between people with and without psoriasis using an age\u2010, sex\u2010 and primary care practice\u2010matched cohort of adults aged \u226540\u2009years from the Clinical Practice Research Datalink Aurum in England (1997\u20132021) linked to hospital admissions data, analysed with stratified Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 360,014 individuals with psoriasis and 1,799,617 without, psoriasis was associated with a small increased risk of all\u2010cause dementia (adjusted hazard ratio [aHR] 1.06, 95% CI 1.04\u20131.08; absolute rate difference 24 per 100,000 person\u2010years). Strength of association increased with time since psoriasis diagnosis (e.g. aHR 0.99, 0.96\u20131.03 within 0 to 5\u2009years; 1.20, 1.05\u20131.37 within 20 to 25\u2009years). The association was stronger for vascular dementia (aHR 1.10, 1.06\u20131.14) than Alzheimer's dementia (aHR 1.03, 1.00\u20131.06). Hazard ratios were larger for severe psoriasis (all\u2010cause aHR 1.32, 1.25\u20131.39; vascular aHR 1.58, 1.44\u20131.74; Alzheimer's aHR 1.11, 1.02\u20131.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Long\u2010term risk of all\u2010cause dementia and vascular dementia, but not Alzheimer's dementia, was slightly higher in people with psoriasis, but absolute risk differences were small. Risks were more substantially raised with time since psoriasis diagnosis and in severe psoriasis compared to mild to moderate psoriasis, suggesting a potential dose\u2013response relationship.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52283","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T06:40:21Z","timestamp":1735800021000},"page":"393-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Psoriasis and dementia: A population\u2010based matched cohort study of adults in England"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-2381","authenticated-orcid":false,"given":"Julian","family":"Matthewman","sequence":"first","affiliation":[{"name":"Department of Non\u2010Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine  Keppel Street London WC1E 7HT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-410X","authenticated-orcid":false,"given":"Kathryn E.","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine  Keppel Street London WC1E 7HT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-7094","authenticated-orcid":false,"given":"Sharon L.","family":"Cadogan","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine  Keppel Street London WC1E 7HT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7736-6946","authenticated-orcid":false,"given":"Katrina","family":"Abuabara","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Francisco  1701 Divisadero Street San Francisco California 94115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-1144","authenticated-orcid":false,"given":"Catherine","family":"Smith","sequence":"additional","affiliation":[{"name":"King's College London St John's Institute of Dermatology  2 Lambeth Palace Rd London SE1 7EP UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5364-8757","authenticated-orcid":false,"given":"Krishnan","family":"Bhaskaran","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine  Keppel Street London WC1E 7HT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-7441","authenticated-orcid":false,"given":"Sin\u00e9ad M.","family":"Langan","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine  Keppel Street London WC1E 7HT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-3180","authenticated-orcid":false,"given":"Charlotte","family":"Warren\u2010Gash","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine  Keppel Street London WC1E 7HT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19169"},{"key":"e_1_2_12_3_1","unstructured":"Alzheimer's Disease International Patterson C.World Alzheimer Report 2018: The State of the Art of Dementia Research: New Frontiers.2018. Accessed October 3 2024.https:\/\/www.alzint.org\/resource\/world\u2010alzheimer\u2010report\u20102018\/"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls187"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-319148"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00556-w"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101046"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.09.003"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63550-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-00420-8"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-220060"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2016-207809"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201489"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.046"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02057-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.09.052"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_732_19"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2020.12.007"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.570992"},{"key":"e_1_2_12_21_1","unstructured":"Clinical Practice Research Datalink.CPRD Aurum March 2023.2023. Accessed December 22 2023.https:\/\/www.cprd.com\/cprd\u2010aurum\u2010march\u20102023\u2010dataset"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz034"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1068\/c0240"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1068\/a37168"},{"key":"e_1_2_12_25_1","unstructured":"Department for Communities and Local Government.The English Indices of Deprivation 2015\u2013Frequently Asked Questions (FAQs).2015. Accessed October 3 2024.https:\/\/assets.publishing.service.gov.uk\/media\/5a80450ced915d74e33f9739\/English_Indices_of_Deprivation_2015_\u2010_Frequently_Asked_Questions_Dec_2016.pdf"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10134.x"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000001767"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S206770"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199026"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdt116"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12963-023-00302-0"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003389"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw318"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.058"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.11.014"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.06.053"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000062"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22926"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230234"}],"container-title":["Annals of Clinical and Translational Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acn3.52283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:07:18Z","timestamp":1746187638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.52283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/acn3.52283"],"URL":"https:\/\/doi.org\/10.1002\/acn3.52283","archive":["Portico"],"relation":{},"ISSN":["2328-9503","2328-9503"],"issn-type":[{"value":"2328-9503","type":"print"},{"value":"2328-9503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}