{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:15:02Z","timestamp":1785762902330,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23NS131586"],"award-info":[{"award-number":["K23NS131586"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined whether riluzole treatment modifies the associations between the dietary glycemic index (GI) and load (GL) and disease progression in amyotrophic lateral sclerosis (ALS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sporadic ALS patients in the Multicenter Cohort Study of Oxidative Stress who completed a baseline food frequency questionnaire were included (<jats:italic>n<\/jats:italic>\u2009=\u2009304). Interactions between baseline riluzole treatment and GI\/GL on functional decline and tracheostomy\u2010free survival were examined using linear regression and Cox proportional hazard models adjusted for covariates. Age, sex, disease duration, diagnostic certainty, body mass index, bulbar onset, revised ALS functional rating scale (ALSFRS\u2010r) total score, and forced vital capacity, from baseline were included as covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline higher GI and GL were associated with less decline of ALSFRS\u2010r total score at 3\u2010month follow\u2010up in the riluzole treatment group (RTG) but not in the no\u2010riluzole group (NRG). When quartile groups were used, GI second [\u03b2\u2009=\u2009\u22121.9, 95% CI (\u22124.1, \u22120.2), <jats:italic>p<\/jats:italic>\u2009=\u20090.07], third [\u03b2\u2009=\u2009\u22123.0, 95% CI (\u22125.1, \u22120.8), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01] and fourth [\u03b2\u2009=\u2009\u22122.2, 95% CI (\u22124.3, \u22120.01), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05] quartile groups were associated with less ALSFRS\u2010r decline at 3\u2010months compared to the first quartile group (GI\u2009&lt;\u200947.2) among the RTG. Similarly, GL fourth quartile group (GL\u2009&gt;\u2009109.5) was associated with less ALSFRS\u2010r decline at 3 months compared to the first quartile group [\u03b2\u2009=\u2009\u22122.6, 95% CI (\u22124.7, \u22120.5), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05] among the RTG. In NRG, no statistically significant differences in ALSFRS\u2010r decline were found among GI\/GL quartile groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>High dietary GI and GL are associated with a slower functional decline only among ALS patients taking riluzole.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52294","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T10:41:54Z","timestamp":1736419314000},"page":"491-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interaction between riluzole treatment and dietary glycemic index in the disease progression of amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-9622","authenticated-orcid":false,"given":"Ikjae","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology, Columbia University Irving 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam","family":"Factor\u2010Litvak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Columbia University Mailman School of Public Health  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeri W.","family":"Nieves","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Columbia University Mailman School of Public Health  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2009.00116.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403033300901"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"S242","article-title":"A confirmatory dose\u2010ranging study of riluzole in ALS","volume":"47","author":"Lacomblez 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