{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:48:37Z","timestamp":1791460117822,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016220","name":"Georgia Clinical and Translational Science Alliance","doi-asserted-by":"publisher","award":["UM1TR004400"],"award-info":[{"award-number":["UM1TR004400"]}],"id":[{"id":"10.13039\/100016220","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic approaches. We investigated the efficacy of liraglutide as an adjunctive therapy in IIH management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study, analyzing adult patients with IIH. Through propensity score matching, we compared patients receiving liraglutide alongside standard therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009204) with those receiving standard therapy alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009204). Primary outcomes included papilledema, headache manifestations, and visual disturbances, assessed at 3, 6, 12, and 24\u2009months posttreatment initiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our matched cohorts were predominantly female (95.1% vs. 97.1%) with comparable mean ages (37.6 vs. 37.3\u2009years). Liraglutide treatment demonstrated significant reduction in papilledema risk at 3\u2009months (RR 0.333, 95% CI 0.167\u20130.664,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), with sustained benefits throughout 24\u2009months (RR 0.524, 95% CI 0.325\u20130.845,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). While improvements were observed in visual disturbances, headache symptoms, and refractory IIH cases, these did not reach statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Our findings suggest that liraglutide as an adjunctive therapy significantly improves papilledema outcomes in IIH patients, with the greatest effect observed at 3\u2009months and sustained benefits over 2\u2009years. This study provides promising evidence for liraglutide's role in IIH management, particularly in addressing papilledema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acn3.52300","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T01:39:51Z","timestamp":1739497191000},"page":"746-755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Liraglutide for idiopathic intracranial hypertension: a real\u2010world propensity score\u2010matched study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4256-0159","authenticated-orcid":false,"given":"Ahmed Y.","family":"Azzam","sequence":"first","affiliation":[{"name":"Montefiore\u2010Einstein Cerebrovascular Research Lab Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Neurological Surgery, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New 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A.","family":"Azab","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M.","family":"Morsy","sequence":"additional","affiliation":[{"name":"October 6 University Hospital October 6 University  6th of October City, Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Elamin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Jordan Hospital  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Elswedy","sequence":"additional","affiliation":[{"name":"Biomedicinskt Centrum BMC Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oday","family":"Atallah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7993-7467","authenticated-orcid":false,"given":"Hana J.","family":"Abukhadijah","sequence":"additional","affiliation":[{"name":"Medical Research Center Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-5699","authenticated-orcid":false,"given":"Adam A.","family":"Dmytriw","sequence":"additional","affiliation":[{"name":"Neuroendovascular Program, Massachusetts General Hospital &amp; Brigham and Women's Hospital Harvard University  Boston Massachusetts USA"},{"name":"Neurovascular Centre, Divisions of Therapeutic Neuroradiology &amp; Neurosurgery, St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Baker","sequence":"additional","affiliation":[{"name":"Montefiore\u2010Einstein Cerebrovascular 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