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However, replication studies on the genetic variants have yielded inconsistent results. In our case\u2013control study, we show that the <jats:italic>LINC00323<\/jats:italic> variant, identified in a European GWAS study, is associated with an increased risk of ET in our Asian cohort. Our results corroborate the association of this risk variant with ET shared by diverse ethnicities. Functional studies of this variant have the potential to identify novel therapeutic targets for the general ET population.<\/jats:p>","DOI":"10.1002\/acn3.52303","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:05:42Z","timestamp":1745996742000},"page":"1504-1505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>LINC00323<\/i> variant is associated with increased risk of essential tremor"],"prefix":"10.1002","volume":"12","author":[{"given":"Brendan","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Neurology National Neuroscience Institute  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebonne","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Research National Neuroscience Institute  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao 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