{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:07:08Z","timestamp":1786421228781,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U54NS115054"],"award-info":[{"award-number":["U54NS115054"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myasthenia gravis (MG) clinical trials typically allow rescue therapy during follow\u2010up in the event of marked worsening of MG symptoms. Failure to appropriately address rescue therapy in defining treatment effects and planning statistical analyses may yield biased estimates, increase false positive rates, or decrease statistical power \u2013 all of which increase the risk that inaccurate information influences patient care. In alignment with recent International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines, we review strategies based on the estimand framework that produce rigorously defined treatment effects in MG trials where rescue therapy may be administered. We also discuss the interpretation, clinical relevance, and pitfalls of each strategy in the context of MG trials, suggesting circumstances in which a strategy would or would not be appropriate. Finally, we outline available statistical methods for estimating treatment effects based on each strategy. As primary endpoints and statistical analyses for trials must be defined prior to conducting the study, it is necessary to consider how to address rescue therapy during study planning.<\/jats:p>","DOI":"10.1002\/acn3.52309","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:40:31Z","timestamp":1744864831000},"page":"888-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Handling rescue therapy in myasthenia gravis clinical trials: why it matters and why you should care"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-9097","authenticated-orcid":false,"given":"Justin M.","family":"Leach","sequence":"first","affiliation":[{"name":"Department of Biostatistics University of Alabama at Birmingham  Birmingham Alabama 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