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GM atrophy was assessed using univariate, voxel\u2010based morphometry, and multivariate techniques, source\u2010based morphometry. Structural disconnectivity secondary to white matter lesions was evaluated using the network modification tool. Mediation analyses explored relationships between ethnoracial groups, white matter lesions, structural disconnectivity, and gray matter atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>B\u2010MS and H\u2010MS generally exhibited greater gray matter atrophy compared to W\u2010MS, particularly in temporal, parahippocampal, precuneus, and cuneus GM. Structural disconnectivity differences were most prominent in the hippocampal, cingulate, precuneus, and deep gray matter regions. Mediation analyses revealed that lesion load significantly mediated group differences in global GM atrophy (percent mediated\u2009=\u200952.4%), while structural disconnectivity mediated some differences in specific gray matter components, notably in deep gray matter, insular, and anterior cingulate regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Significant ethnoracial disparities exist in GM atrophy and its patterns among diverse MS patients, partially mediated by white matter lesions and consequent structural disconnectivity. These findings underscore the importance of considering ethnoracial factors in MS research and clinical practice, potentially informing personalized treatment strategies and emphasizing the need for diverse representation in clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.52311","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T10:14:28Z","timestamp":1739787268000},"page":"615-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ethnoracial disparities in gray matter atrophy are mediated by structural disconnectivity in multiple sclerosis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7633-5961","authenticated-orcid":false,"given":"Ahmed","family":"Bayoumi","sequence":"first","affiliation":[{"name":"Department of Neurology McGovern Medical School at UTHealth  Houston Texas 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