{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:12:48Z","timestamp":1792375968053,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T00:00:00Z","timestamp":1520640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In neuro Beh\u00e7et disease with multiple sclerosis\u2010like features, diagnosis could be challenging. Here, we studied the cerebrospinal fluid and serum inflammatory profile of 11 neuro Beh\u00e7et and 21 relapsing\u2010remitting multiple sclerosis patients. Between the soluble factors analyzed (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>9, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><jats:italic>\u03b1<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>6, <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>13, <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>10, <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>8, <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content><jats:italic>\u03b3<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>10, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>23, and others) we found <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>9 increased in neuro Beh\u00e7et serum compared to multiple sclerosis and decreased in cerebrospinal fluid. Furthermore, neuro Beh\u00e7et analysis of circulating natural killer <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56<jats:styled-content style=\"fixed-case\"><jats:sub>DIM<\/jats:sub><\/jats:styled-content> subset suggests their potential involvement in increased <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>9 production. We believe that these findings may have a translational utility in clinical practice.<\/jats:p>","DOI":"10.1002\/acn3.538","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T05:11:02Z","timestamp":1520658662000},"page":"493-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["CSF\/serum matrix metallopeptidase\u20109 ratio discriminates neuro Beh\u00e7et from multiple sclerosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Alessandra","family":"Aldinucci","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug and Child Health University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bonechi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug and Child Health University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Biagioli","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Repice","sequence":"additional","affiliation":[{"name":"Neurological Division II Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario M.","family":"D'Elios","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Emmi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence 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