{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:50:24Z","timestamp":1789905024066,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["734548"],"award-info":[{"award-number":["734548"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009054","name":"International Centre for Diarrhoeal Disease Research, Bangladesh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n Previous studies have associated Guillain\u2013Barr\u00e9 syndrome (\n GBS<\/jats:styled-content>\n ) with Zika virus (\n ZIKV<\/jats:styled-content>\n ) outbreaks in South America and Oceania. In Asia,\n ZIKV<\/jats:styled-content>\n is known to circulate widely, but the association with Guillain\u2013Barr\u00e9 syndrome is unclear. We investigated whether endemic\n ZIKV<\/jats:styled-content>\n infection is associated with the development of\n GBS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A prospective study was conducted from 2011 to 2015 in Bangladesh. A total of 418 patients and 418 healthy family controls were included in the study. Patients were diagnosed with\n GBS<\/jats:styled-content>\n prior to inclusion according to established criteria. Detailed information on the epidemiology, clinical presentation, electrophysiology, diagnosis, disease severity, and clinical course were obtained during a follow\u2010up of 1 year using a predefined protocol.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n ZIKV<\/jats:styled-content>\n \u2010neutralizing antibodies were detected in our study from 2013 onwards. The prevalence of\n ZIKV<\/jats:styled-content>\n \u2010neutralizing antibodies was not significantly higher in patients with\n GBS<\/jats:styled-content>\n compared to healthy controls (\n OR<\/jats:styled-content>\n 2.23,\n P<\/jats:italic>\n = 0.14, 95%\n CI<\/jats:styled-content>\n 0.77\u20136.53). Serological evidence for prior\n ZIKV<\/jats:styled-content>\n infection in patients with\n GBS<\/jats:styled-content>\n was associated with more frequent cranial, sensory, and autonomic nerve involvement compared to\n GBS<\/jats:styled-content>\n patients with\n Campylobacter jejuni<\/jats:italic>\n , the predominant preceding infection in\n GBS<\/jats:styled-content>\n worldwide. Nerve\u2010conduction studies revealed that\n ZIKV<\/jats:styled-content>\n antibodies were associated with a demyelinating subtype of\n GBS<\/jats:styled-content>\n , while\n C<\/jats:italic>\n .\n jejuni<\/jats:italic>\n infections were related to an axonal subtype.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n \n No significant association was found between\n ZIKV<\/jats:styled-content>\n infection and\n GBS<\/jats:styled-content>\n in Bangladesh, but\n GBS<\/jats:styled-content>\n following\n ZIKV<\/jats:styled-content>\n infection was characterized by a distinct clinical and electrophysiological subtype compared to\n C<\/jats:italic>\n .\n jejuni<\/jats:italic>\n infection. These findings indicate that\n ZIKV<\/jats:styled-content>\n may precede a specific\n GBS<\/jats:styled-content>\n subtype but the risk is low.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acn3.556","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T17:52:17Z","timestamp":1523037137000},"page":"606-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Zika virus and Guillain\u2013Barr\u00e9 syndrome in Bangladesh"],"prefix":"10.1002","volume":"5","author":[{"given":"Corine H.","family":"GeurtsvanKessel","sequence":"first","affiliation":[{"name":"Department of Viroscience Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhahirul","family":"Islam","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services Division International Centre for Diarrhoeal Disease Research, (icddr,b) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Badrul","family":"Islam","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services Division International Centre for Diarrhoeal Disease Research, (icddr,b) Dhaka Bangladesh"},{"name":"Department of Medical Microbiology and Infectious Diseases Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Kamga","sequence":"additional","affiliation":[{"name":"Department of Viroscience Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nowshin","family":"Papri","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services Division International Centre for Diarrhoeal Disease Research, (icddr,b) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A. M. C.","family":"van de Vijver","sequence":"additional","affiliation":[{"name":"Department of Viroscience Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Reusken","sequence":"additional","affiliation":[{"name":"Department of Viroscience Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Mogling","sequence":"additional","affiliation":[{"name":"Department of Viroscience Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid P.","family":"Heikema","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israt","family":"Jahan","sequence":"additional","affiliation":[{"name":"Laboratory Sciences and Services Division International Centre for Diarrhoeal Disease Research, (icddr,b) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence K.","family":"Pradel","sequence":"additional","affiliation":[{"name":"Fondation M\u00e9rieux Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Pavlicek","sequence":"additional","affiliation":[{"name":"Naval Medical Research Center\u2010Asia Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quazi D.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"National Institute of Neurosciences and Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion P. 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