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Both pairwise and multifactorial analyses were conducted to identify factors associated with continued seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven of 38 patients continued to have seizures during the follow\u2010up period. On univariate analysis, the number of neurocysticercosis lesions, number of bands on the baseline neurocysticercosis western blot, edema volumes on follow\u2010up <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scans, edema volume changes between baseline and follow\u2010up images, and proportion of calcified lesions with perilesional edema were all significantly increased in subjects who had persistent seizures during the 18\u2010month follow\u2010up period. On multivariate analyses using recursive partition and random forest algorithms, variables associated with persistent seizures included: the number of total and calcified lesions, presence of perilesional edema, the rate of change in the lesion and edema volumes from baseline to follow\u2010up, and the number of bands on the neurocysticercosis western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Measures of both inflammation and disease burden are key risk factors for persistent seizures despite anticonvulsant treatments in patients with neurocysticercosis. Inflammation is therefore a potentially modifiable risk factor for the frequently seen severe seizure disorders in patients with neurocysticercosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.562","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T01:44:05Z","timestamp":1523411045000},"page":"630-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Inflammation is a key risk factor for persistent seizures in neurocysticercosis"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5509-6458","authenticated-orcid":false,"given":"Jesica A.","family":"Herrick","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Immunology, and International Medicine University of Illinois at Chicago Chicago 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