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The aim of this neuroimaging study was to analyze the disease\u2010specific brain changes in patients with phobic postural vertigo (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured brain morphology, task response, and functional connectivity in 44 patients with <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> and 44 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analyses revealed a relative structural increase in regions of the prefrontal cortex and the associated thalamic projection zones as well as in the primary motor cortex. Morphological increases in the ventrolateral prefrontal cortex positively correlated with disease duration, whereas increases in dorsolateral, medial, and ventromedial prefrontal areas positively correlated with the Beck depression index. Visual motion stimulation caused an increased task\u2010dependent activity in the subgenual anterior cingulum and a significantly longer duration of the motion aftereffect in the patients. Task\u2010based functional connectivity analyses revealed aberrant involvement of interoceptive, fear generalization, and orbitofrontal networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our findings agree with some of the typical characteristics of functional dizziness syndromes, for example, excessive self\u2010awareness, anxious appraisal, and obsessive controlling of posture. This first evidence indicates that the disease\u2010specific mechanisms underlying <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> are related to networks involved in mood regulation, fear generalization, interoception, and cognitive control. They do not seem to be the result of aberrant processing in cortical visual, visual motion, or vestibular regions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.570","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T04:29:36Z","timestamp":1526358576000},"page":"717-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Cortical alterations in phobic postural vertigo \u2013 a multimodal imaging approach"],"prefix":"10.1002","volume":"5","author":[{"given":"Pauline","family":"Popp","sequence":"first","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"Graduate School of Systemic Neurosciences Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"zu Eulenburg","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"Graduate School of Systemic Neurosciences Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stephan","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"Graduate School of Systemic Neurosciences Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"B\u00f6gle","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"Graduate School of Systemic Neurosciences Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Habs","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Henningsen","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy Technical University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Feuerecker","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"Graduate School of Systemic Neurosciences Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders Ludwig\u2010Maximilians Universit\u00e4t Munich Germany"},{"name":"SyNergy Munich Cluster of Systems Neurology Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7803-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000417"},{"key":"e_1_2_8_4_1","unstructured":"International Classification of Diseases ICD\u201011Beta Draft\u2014Joint Linearization for Mortality and Morbidity Statistics [Internet]. 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