{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:51:54Z","timestamp":1787503914550,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["FNOs\/2015"],"award-info":[{"award-number":["FNOs\/2015"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Repetitive transcranial magnetic stimulation (\n                      <jats:styled-content style=\"fixed-case\">rTMS<\/jats:styled-content>\n                      ) is currently being tested for suppressing the symptoms of subjective chronic primary tinnitus, although its effect is controversial. The aim of this randomized double\u2010blinded controlled trial was to determine the effect of\n                      <jats:styled-content style=\"fixed-case\">rTMS<\/jats:styled-content>\n                      with unique settings for tinnitus treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010three adult patients suffering from chronic subjective unilateral or bilateral nonpulsatile primary tinnitus for at least 6 months were randomly assigned to\n                      <jats:styled-content style=\"fixed-case\">rTMS<\/jats:styled-content>\n                      (group 1,\n                      <jats:italic>n<\/jats:italic>\n                      = 20), sham stimulation (group 2,\n                      <jats:italic>n<\/jats:italic>\n                      = 12), or medicament therapy only (group 3,\n                      <jats:italic>n<\/jats:italic>\n                      = 21). The dorsolateral prefrontal cortex (frequency 25 Hz, 300 pulses, and 80% resting motor threshold [\n                      <jats:styled-content style=\"fixed-case\">RMT<\/jats:styled-content>\n                      ]) on the left side and primary auditory cortex (1 Hz, 1000 pulses, 110%\n                      <jats:styled-content style=\"fixed-case\">RMT<\/jats:styled-content>\n                      ) were stimulated on both sides in patients in group 1 for 5 consecutive days. The Tinnitus Reaction Questionnaire (\n                      <jats:styled-content style=\"fixed-case\">TRQ<\/jats:styled-content>\n                      ), Tinnitus Handicap Questionnaire (\n                      <jats:styled-content style=\"fixed-case\">THQ<\/jats:styled-content>\n                      ), Tinnitus Handicap Inventory (\n                      <jats:styled-content style=\"fixed-case\">THI<\/jats:styled-content>\n                      ), Beck Depression Inventory (\n                      <jats:styled-content style=\"fixed-case\">BDI<\/jats:styled-content>\n                      ), pure\u2010tone audiometry with Fowler scoring of hearing loss, and tinnitus analysis were used to evaluate tinnitus in all patients. Data were recorded the day the patient was included in the study and at 1\u2010 and 6\u2010month follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study groups were homogenous. No significant effect of\n                      <jats:styled-content style=\"fixed-case\">rTMS<\/jats:styled-content>\n                      was found at 1 or 6 months based on the\n                      <jats:styled-content style=\"fixed-case\">BDI<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">THQ<\/jats:styled-content>\n                      , and\n                      <jats:styled-content style=\"fixed-case\">TRQ<\/jats:styled-content>\n                      scores or tinnitus masking. There was a significant but clinically irrelevant effect on the\n                      <jats:styled-content style=\"fixed-case\">THI<\/jats:styled-content>\n                      score after 1 and 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      No significant effect of bilateral low\u2010frequency\n                      <jats:styled-content style=\"fixed-case\">rTMS<\/jats:styled-content>\n                      of the primary auditory cortex and high\u2010frequency stimulation of the left dorsolateral prefrontal cortex was demonstrated.\n                    <\/jats:p>\n                  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