{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:42:47Z","timestamp":1781739767029,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special","doi-asserted-by":"publisher","award":["2016\u20104\u20101032"],"award-info":[{"award-number":["2016\u20104\u20101032"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX201706"],"award-info":[{"award-number":["ZYLX201706"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Remote ischemic conditioning (<jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>) has been demonstrated to be safe and feasible for patients with acute ischemic stroke (<jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>), as well as for those receiving intravenous thrombolysis. We assessed the safety and feasibility of <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> patients undergoing endovascular treatment (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a pilot study with patients with <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> who were suspected of having an emergent large\u2010vessel occlusion in the anterior circulation and who were scheduled for <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> within 6 hours of ictus. Four cycles of <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> were performed before recanalization, immediately following recanalization, and once daily for the subsequent 7 days. The primary outcome was any serious <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>\u2010related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty subjects, aged 66.1 \u00b1 12.1 years, were recruited. No subject experienced serious <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>\u2010related adverse events. The intracranial pressure, cranial perfusion pressure, mean arterial pressure, heart rate, middle cerebral artery peak systolic flow velocity, and pulsatility index did not change significantly before, during, or after the limb ischemia (<jats:italic>P<\/jats:italic> &gt; 0.1 for all). Of 80 cycles, 71 (89%) were completed before recanalization and 80 (100%) were completed immediately after recanalization; 444 of 560 cycles (78%) were completed within 7 days posttreatment. No patients had to stop <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> because it affected routine clinical managements. Six subjects (30%) experienced intracerebral hemorrhage, which was symptomatic in one case (5%). At the 3\u2010month follow\u2010up, 11 subjects (55%) had achieved functional independence, and two subjects (10%) died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> appears to be safe and feasible for patients with <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> undergoing <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. Investigations are urgently needed to determine the efficacy of <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.588","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T06:06:37Z","timestamp":1528351597000},"page":"850-856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Remote ischemic conditioning for acute stroke patients treated with thrombectomy"],"prefix":"10.1002","volume":"5","author":[{"given":"Wenbo","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine Xuanwu Hospital Capital Medical University Beijing 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