{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:42:42Z","timestamp":1792154562342,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Tilray","award":["R_2016_0011967"],"award-info":[{"award-number":["R_2016_0011967"]}]},{"name":"Little Rocky Project"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n Both \u0394\n 9<\/jats:sup>\n Tetrahydrocannabidiol (\n THC<\/jats:styled-content>\n ) and cannabidiol (\n CBD<\/jats:styled-content>\n ) components of cannabis, have been shown to have anticonvulsant effects. Cannabis oils are used to treat seizures in drug\u2010resistant epilepsy (\n DRE<\/jats:styled-content>\n ). Recent trials provide data on dosing, side effects, and efficacy of\n CBD<\/jats:styled-content>\n , yet there is a paucity of information on\n THC<\/jats:styled-content>\n in epilepsy. Primary objective was to establish dosing and tolerability of\n TIL<\/jats:styled-content>\n \u2010\n TC<\/jats:styled-content>\n 150 \u2010 a cannabis plant extract produced by Tilray\n \u00ae<\/jats:sup>\n , containing 100\u00a0mg\/mL\n CBD<\/jats:styled-content>\n and 2\u00a0mg\/mL\n THC<\/jats:styled-content>\n \u2010 in children with Dravet syndrome. Secondary objectives were to assess impact of therapy on seizures, electroencephalogram (\n EEG<\/jats:styled-content>\n ) and quality of life.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Twenty children received add\u2010on therapy with\n TIL<\/jats:styled-content>\n \u2010\n TC<\/jats:styled-content>\n 150. The dose ranged from 2 to 16\u00a0mg\/kg\/day of\n CBD<\/jats:styled-content>\n and 0.04 to 0.32\u00a0mg\/kg\/day of\n THC<\/jats:styled-content>\n . Patients were monitored for tolerability and adverse events, and secondary objectives.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Nineteen participants completed the 20\u2010week intervention. Mean dose\u00a0achieved was 13.3\u00a0mg\/kg\/day of\n CBD<\/jats:styled-content>\n (range 7\u201316\u00a0mg\/kg\/day) and 0.27\u00a0mg\/kg\/day of\n THC<\/jats:styled-content>\n (range 0.14\u20130.32\u00a0mg\/kg\/day). Adverse events, common during titration included somnolence, anorexia, and diarrhea. Abnormalities of liver transaminases and platelets were observed with concomitant valproic acid therapy. There was a statistically significant improvement in quality of life, reduction in\n EEG<\/jats:styled-content>\n spike activity, and median motor seizure reduction of 70.6%, with 50% responder rate of 63%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n TIL<\/jats:styled-content>\n \u2010\n TC<\/jats:styled-content>\n 150 was safe and well tolerated in our subjects.\n TIL<\/jats:styled-content>\n \u2010\n TC<\/jats:styled-content>\n 150 treatment resulted in a reduction in seizure counts, spike index on\n EEG<\/jats:styled-content>\n , and improved quality of life measures. This study provides safety and dosing information for\n THC<\/jats:styled-content>\n \u2010containing cannabinoid preparations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acn3.621","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T12:36:10Z","timestamp":1533213370000},"page":"1077-1088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["A prospective open\u2010label trial of a\n CBD<\/scp>\n \/\n THC<\/scp>\n cannabis oil in dravet syndrome"],"prefix":"10.1002","volume":"5","author":[{"given":"Bl\u00e1thnaid","family":"McCoy","sequence":"first","affiliation":[{"name":"Division of Neurology the Hospital for Sick Children Toronto Canada"},{"name":"Department of Pediatrics University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Zak","sequence":"additional","affiliation":[{"name":"Division of Neurology the Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Al\u2010Mehmadi","sequence":"additional","affiliation":[{"name":"Division of Neurology the Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Kabir","sequence":"additional","affiliation":[{"name":"Division of Neurology the Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenda","family":"Alhadid","sequence":"additional","affiliation":[{"name":"Division of Neurology the Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyla","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Psychology the Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychology the Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Neurology the Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Whitney","sequence":"additional","affiliation":[{"name":"Division of Neurology the Hospital for Sick Children Toronto Canada"},{"name":"Department of Pediatrics University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Sinopoli","sequence":"additional","affiliation":[{"name":"Department of Psychology the Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"O. 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