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We first showed a decreased number of circulating <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>24<jats:sup>++<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>38<jats:sup>++<\/jats:sup> Breg cells and an altered functionality of Breg cells in untreated myasthenia gravis patients. Next, we demonstrated that the proportion of circulating Breg cells was restored in myasthenia gravis patients after thymectomy, probably as Breg cells could be sequestered in the myasthenia gravis thymus. In contrast, corticosteroid treatments did not restore and decreased even more the proportion of Breg cells in myasthenia gravis patients. These results clearly demonstrated that two distinct immunomodulatory therapies affect differentially Breg cells.<\/jats:p>","DOI":"10.1002\/acn3.645","type":"journal-article","created":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T04:08:33Z","timestamp":1537675713000},"page":"1408-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Regulatory B cells in myasthenia gravis are differentially affected by therapies"],"prefix":"10.1002","volume":"5","author":[{"given":"Vuslat","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Neuroscience Aziz Sancar Institute of Experimental Medical Research (DETAE) Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Maillard","sequence":"additional","affiliation":[{"name":"Center of Research in Myology Sorbonne University INSERM AIM UMRS974 Paris 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