{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:14:52Z","timestamp":1791328492835,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81471203"],"award-info":[{"award-number":["81471203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between the perfusion magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and vertebrobasilar dolichoectasia (<jats:styled-content style=\"fixed-case\">VBD<\/jats:styled-content>) in vertigo patients and at least one vascular risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 289 patients with vertigo (spinning, swaying, nausea, vomiting, and unsteady gait) who performed multimode <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. Maximum diameter and tortuous parameters of the basilar artery and vertebral arteries were calculated using magnetic resonance angiography. Relative cerebral blood volume (<jats:styled-content style=\"fixed-case\">rCBV<\/jats:styled-content>), relative cerebral blood flow (<jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content>), mean transit time (<jats:styled-content style=\"fixed-case\">MTT<\/jats:styled-content>), and time to peak (<jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>) maps were evaluated by dynamic susceptibility contrast\u2010enhanced perfusion imaging. Association of perfusion <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">VBD<\/jats:styled-content> was evaluated by nonparametric tests and receiver\u2010operating characteristic curve was constructed to predict posterior ischemic stroke in <jats:styled-content style=\"fixed-case\">VBD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">VBD<\/jats:styled-content> was 26.6% (<jats:italic>n<\/jats:italic>\u00a0=\u00a077\/289) in our study. Male gender was the risk factor of <jats:styled-content style=\"fixed-case\">VBD<\/jats:styled-content> by multivariate analysis. <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> diameter was significant statistics between ischemic stroke and nonischemic stroke patients. <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> in bilateral lower cerebellum, superior cerebellum, bilateral pons, and occipital and temporal lobes region of interests was significantly delayed in <jats:styled-content style=\"fixed-case\">VBD<\/jats:styled-content> versus non\u2010<jats:styled-content style=\"fixed-case\">VBD<\/jats:styled-content> patients, while <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> rCBV<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">MTT<\/jats:styled-content> parameters were not significant differences. <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> in the right temporal lobe delayed by 21.96\u00a0ms was the best predictive value and the mean <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> predictive threshold value in all <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s was 22.67\u00a0\u00b1\u00a01.48\u00a0ms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">VBD<\/jats:styled-content> leads to the hypoperfusion of posterior circulation territory characterized by delayed <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>. Delayed <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> in cerebellum, pons, and occipital and temporal lobes fed by vertebrobasilar arteries predicted the occurrence of posterior ischemic stroke in <jats:styled-content style=\"fixed-case\">VBD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.665","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T08:20:46Z","timestamp":1539332446000},"page":"1562-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Perfusion by delayed time to peak in vertebrobasilar dolichoectasia patients with vertigo"],"prefix":"10.1002","volume":"5","author":[{"given":"Yan Fang","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Neurology People's Hospital of Zhengzhou Affiliated to Southern Medical University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Henan University of CM Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Pei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology People's Hospital of Zhengzhou Affiliated to Southern Medical University Zhengzhou China"},{"name":"Department of Neurology The First Affiliated Hospital of Henan University of CM Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Henan University of CM Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology People's Hospital of Zhengzhou Affiliated to Southern Medical University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suo","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Image People's Hospital of Zhengzhou Affiliated to Southern Medical University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.181"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05114.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000286947.89193.f3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00089-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00344"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016150032"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.169805"},{"key":"e_1_2_6_9_1","first-page":"22","article-title":"Vertebrobasilar dolichoectasia diagnosed by maganetic resonance angiography and risk of stroke and death: a cohort study","volume":"75","author":"Ubogu EE","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.00993.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12177"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.09.024"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15447"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015507"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2003.10.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.990549"},{"key":"e_1_2_6_17_1","first-page":"55","article-title":"High\u2010resolution computed tomography of the basilar artery: 1. 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