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Novel applications of\n                    <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                    continue to emerge including treatment of various psychiatric conditions (e.g. obsessive\u2010compulsive disorder, major depression) and cognitive disorders such as Alzheimer's disease. Despite widening therapeutic applications, our understanding of the mechanisms underlying\n                    <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                    remains limited. In addition to modulation of local and network\u2010wide neuronal activity, growing evidence suggests that\n                    <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                    may also have important neuroprotective effects in the brain by limiting synaptic dysfunction and neuronal loss in neurodegenerative disorders. In this review, we consider evidence from preclinical and clinical studies of\n                    <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>\n                    in Parkinson's disease, Alzheimer's disease, and epilepsy that suggest chronic stimulation has the potential to mitigate neuronal loss and disease progression.\n                  <\/jats:p>","DOI":"10.1002\/acn3.682","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T23:15:52Z","timestamp":1541718952000},"page":"174-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Deep brain stimulation: potential for neuroprotection"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-318X","authenticated-orcid":false,"given":"Chris","family":"McKinnon","sequence":"first","affiliation":[{"name":"Krembil Research Institute University Health Network Toronto Western 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