{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:17:13Z","timestamp":1786976233186,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A patient with pilomotor seizures post anti\u2010\n                    <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>\n                    1 limbic encephalitis, refractory to immunotherapy and anti\u2010epileptic drugs, was investigated with electroencephalography and magnetoencephalography. Seizures occurred daily (14.9 \u00b1 4.9\/day), with catamenial exacerbation, inducible by hyperventilation. Anterior temporal ictal onsets were heralded (by ~15\u00a0sec) by high amplitude ipsilateral electromagnetic infraslow activity. The catamenial\/ventilatory sensitivity and the infraslow activity (reflecting glial depolarization) suggested an ionic,\n                    <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>\n                    <jats:sub>2<\/jats:sub>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                    \u2010related glioneuronal mechanism. Furosemide decreased seizure frequency by ~33%. Acetazolamide led to immediate seizure freedom, but lost efficacy with daily treatment. A cycling acetazolamide regimen (2\u00a0days on, 4\u00a0days off) plus low\u2010dose topiramate maintained &gt;95% reduction (0.5\u00a0\u00b1\u00a00.9\/day) in seizures.\n                  <\/jats:p>","DOI":"10.1002\/acn3.695","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T03:27:37Z","timestamp":1541993257000},"page":"167-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pilomotor seizures marked by infraslow activity and acetazolamide responsiveness"],"prefix":"10.1002","volume":"6","author":[{"given":"Richard","family":"Wennberg","sequence":"first","affiliation":[{"name":"Krembil Brain Institute Division of Neurology University Health Network University of Toronto Toronto Canada"},{"name":"Mitchell Goldhar MEG Unit Clinical Neurophysiology Laboratory Toronto Western Hospital University of Toronto Toronto 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