{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:47:37Z","timestamp":1792853257962,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005646","name":"Actelion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cerebellar ataxia essentially includes deficient postural control. It remains unclear whether augmented sensory information might help cerebellar patients, as the cerebellum underlies processing of various sensory modalities for postural control. Here, we hypothesized that patients with cerebellar degeneration can still exploit audio\u2010biofeedback (<jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content>) of trunk acceleration as a real\u2010time assistive signal to compensate for deficient postural control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Effects on postural sway during stance were assessed in an <jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content> intervention group versus a no\u2010<jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content> disease control group (23 vs. 17 cerebellar patients) in a clinico\u2010experimental study. A single\u2010session <jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content> paradigm of standing plus short exergaming under <jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content> was applied. Postural sway with eyes open and eyes closed was quantified prior to <jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content>, under <jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content>, and post <jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postural sway in the eyes closed condition was significantly reduced under <jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content>. Both benefit of <jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content> and benefit of vision correlated with the extent of postural sway at baseline, and both types of sensory benefits correlated with each other. Patients with strongest postural sway exhibited reduced postural sway also with eyes open, thus benefitting from both vision and <jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content>. No changes were observed in the no\u2010<jats:styled-content style=\"fixed-case\">ABF<\/jats:styled-content> control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our findings provide proof\u2010of\u2010principle evidence that subjects with cerebellar degeneration are still able to integrate additional sensory modalities to compensate for deficient postural control: They can use auditory cues <jats:italic>functionally similar<\/jats:italic> to vision in the absence of vision, and <jats:italic>additive<\/jats:italic> to vision in the presence of vision (in case of pronounced postural sway). These findings might inform future assistive strategies for cerebellar ataxia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.699","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T16:46:12Z","timestamp":1543423572000},"page":"285-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Real\u2010time use of audio\u2010biofeedback can improve postural sway in patients with degenerative ataxia"],"prefix":"10.1002","volume":"6","author":[{"given":"Zofia","family":"Fleszar","sequence":"first","affiliation":[{"name":"Department of Cognitive Neurology Hertie Institute for Clinical Brain Research T\u00fcbingen Germany"},{"name":"Centre for Integrative Neuroscience (CIN) T\u00fcbingen Germany"},{"name":"Department of Neurodegeneration Hertie Institute for Clinical Brain Research and Centre of Neurology T\u00fcbingen 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