{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:15:21Z","timestamp":1780611321351,"version":"3.54.1"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cavin\u20104 was identified as a potential autoantigen for immune\u2010mediated rippling muscle disease (iRMD). To validate this, we developed and tested various immunoassays, including a cell\u2010based assay (CBA), cavin\u20104 recombinant protein ELISA, and multi\u2010peptide ELISA. Among 19 iRMD patients, all exhibited muscle rippling, and 13 had percussion\u2010induced mounding. All immunoassays demonstrated clinical and analytical specificities greater than 95%. The protein ELISA had the highest sensitivity (94.7%) and specificity (99.9%), outperforming CBA (sensitivity 89.5%, specificity 99.6%) and the multi\u2010peptide ELISA (sensitivity 79.0%, specificity 97.2%). Our results suggest that the cavin\u20104 protein ELISA is a promising tool for high\u2010throughput clinical testing in iRMD.<\/jats:p>","DOI":"10.1002\/acn3.70012","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T08:39:36Z","timestamp":1739781576000},"page":"876-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010Throughput Immunoassays for Cavin\u20104 <scp>IgG<\/scp>: A Diagnostic Tool for Immune\u2010Mediated Rippling Muscle Disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Reghann G.","family":"LaFrance\u2010Corey","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota 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