{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:49:41Z","timestamp":1764175781623,"version":"3.41.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01 AG019724","P30 AG062422","R01 AG062758","U01 AG045390","U19 AG063911","U24 AG21886","R01AG059794"],"award-info":[{"award-number":["P01 AG019724","P30 AG062422","R01 AG062758","U01 AG045390","U19 AG063911","U24 AG21886","R01AG059794"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["U54 NS092089"],"award-info":[{"award-number":["U54 NS092089"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Certain frontotemporal lobar degeneration subtypes, including TDP\u2010A and B, can either occur sporadically or in association with specific genetic mutations. It is uncertain whether syndromic or imaging features previously associated with these patient groups are subtype or genotype specific. Our study sought to discern the similarities and differences between sporadic and genetic TDP\u2010A and TDP\u2010B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We generated individual atrophy maps and extracted mean atrophy scores for regions of interest\u2014frontotemporal, occipitoparietal, thalamus, and cerebellum\u2014in 54 patients with FTLD\u2010TDP types A or B. We calculated asymmetry as the absolute difference in atrophy between right and left frontotemporal regions, and dorsality as the difference in atrophy between dorsal and ventral frontotemporal regions. We used ANCOVAs adjusted for disease severity to compare atrophy extent or imbalance, neuropsychological tests, and behavioral measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For some regions, volumetric differences were found either between TDP subtypes (e.g., worse occipitoparietal and cerebellum atrophy in TDP\u2010A than B), or within subtypes depending on genetic status (e.g., worse thalamic and occipitoparietal atrophy in <jats:italic>C9orf72<\/jats:italic>\u2010associated TDP\u2010B than sporadic TDP\u2010B). While <jats:italic>progranulin<\/jats:italic> mutation\u2010associated TDP\u2010A and sporadic TDP\u2010A cases can be strongly asymmetric, TDP\u2010A and TDP\u2010B associated with <jats:italic>C9orf72<\/jats:italic> tended to be symmetric. TDP\u2010A was more dorsal in atrophy than TDP\u2010B, regardless of genetic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>While some neuroimaging features are FTLD\u2010TDP subtype\u2010specific and do not significantly differ based on genotype, other features differ between sporadic and genetic forms within the same subtype and could decrease accuracy of classification algorithms that group genetic and sporadic cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.70014","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:15:08Z","timestamp":1741742108000},"page":"947-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration <scp>TDP<\/scp>\u201043 A and B"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-0864","authenticated-orcid":false,"given":"Sean","family":"Coulborn","sequence":"first","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhiana","family":"Schafer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashlin R. K.","family":"Roy","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Sokolowski","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah G.","family":"Cryns","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Leichter","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for 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Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Gorno\u2010Tempini","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel H.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences University of California  San Francisco California 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