{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:34:24Z","timestamp":1778798064935,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/01758"],"award-info":[{"award-number":["PI21\/01758"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Huntington's disease (HD) speech\/language disorders have typically been attributed to motor and executive impairment due to striatal dysfunction. In\u2010depth study of linguistic skills and the role of extrastriatal structures in HD is scarce. This study aimed to explore the profile of language compromise in HD and identify the structural neuroimaging correlates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Language and structural correlates were assessed using the Mini Linguistic State Examination (MLSE) in 81 participants (20 HD\u2010ISS 0\u20101, 40 HD\u2010ISS 2\u20103 and 21 controls). Clinical and global cognition measures were also obtained. Imaging data included computed gray matter volume (GMV) and cortical thickness (CTh) values extracted from a general linear model with the MLSE. Correlation analyses were performed with the language components of the MLSE. Multivariate regression analyses were used to explore the predictive ability of the language components on GMV and CTh loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HD individuals showed impaired MLSE performance (84.5\u2009\u00b1\u200912.8), particularly in syntax, motor speech, and to a lesser extent, semantics and phonology. Significant associations were found between linguistic performance and the structural integrity of nodes within the temporo\u2010parietal, fronto\u2010parietal, and fronto\u2010striatal lexical\u2010semantic and syntactic networks. Correlation analyses linked motor speech and syntax with predominantly left fronto\u2010striatal GMV and CTh clusters, while semantics had a bilateral fronto\u2010parietal topography. Multivariate regression analyses showed language domains as independent contributing factors of GMV and CTh loss in classical language\u2010related regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Language impairment is an integral part of the HD cognitive phenotype, with severity associated with structural disintegration in extensive cortico\u2010subcortical territories involved in language production and processing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.70022","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T16:13:51Z","timestamp":1744906431000},"page":"1201-1213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early Language Impairment as an Integral Part of the Cognitive Phenotype in Huntington's Disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8883-4947","authenticated-orcid":false,"given":"Arnau","family":"Puig\u2010Davi","sequence":"first","affiliation":[{"name":"Institute of Neuroscience Universitat Aut\u00f2noma de Barcelona (UAB)  Bellaterra Spain"},{"name":"Movement Disorders Unit, Neurology Department Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Institut de Recerca Sant Pau (IR SANT PAU)  Barcelona Spain"},{"name":"European Huntington's Disease Network  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Franch\u2010Marti","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Department Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Institut de Recerca Sant Pau (IR SANT PAU)  Barcelona Spain"},{"name":"European Huntington's Disease Network  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-5857","authenticated-orcid":false,"given":"I\u00f1igo","family":"Ruiz\u2010Barrio","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Department Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Institut de Recerca Sant Pau (IR SANT PAU)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red\u2010Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-1355","authenticated-orcid":false,"given":"Frederic","family":"Sampedro","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Department Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Institut de Recerca Sant Pau (IR SANT PAU)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red\u2010Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-0484","authenticated-orcid":false,"given":"Jesus","family":"Perez\u2010Perez","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universitat Aut\u00f2noma de Barcelona (UAB)  Bellaterra Spain"},{"name":"Movement Disorders Unit, Neurology Department Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Institut de Recerca Sant Pau (IR SANT PAU)  Barcelona Spain"},{"name":"European Huntington's Disease Network  Ulm Germany"},{"name":"Centro de Investigaci\u00f3n en Red\u2010Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-2708","authenticated-orcid":false,"given":"Jordi A.","family":"Matias\u2010Guiu","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdiSSC). 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