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Transverse relaxation rate (R<jats:sub>2<\/jats:sub>) is a major source of contrast in MRI. This study tested the hypothesis that CAA is associated with R<jats:sub>2<\/jats:sub>, extracted the spatial pattern of CAA\u2010related R<jats:sub>2<\/jats:sub> abnormalities, and evaluated R<jats:sub>2<\/jats:sub> at different CAA severity levels in a large number of community\u2010based older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cerebral hemispheres from 804 older adults who came to autopsy were included. All hemispheres underwent ex\u00a0vivo MRI and detailed neuropathologic examination. R<jats:sub>2<\/jats:sub> maps were generated from ex\u00a0vivo MRI data. Voxel\u2010wise and region\u2010based regression analyses were conducted to investigate the association of R<jats:sub>2<\/jats:sub> with CAA, controlling for other neuropathologies and demographics. R<jats:sub>2<\/jats:sub> values at different CAA severity levels were also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CAA severity was associated with a higher transverse relaxation rate R<jats:sub>2<\/jats:sub> in cortical and juxtacortical frontal and medial temporal lobe regions, and in deep brain structures, independently of other neuropathologies and demographics. R<jats:sub>2<\/jats:sub> abnormalities were significant in severe CAA, but were limited in terms of spatial extent and magnitude in moderate CAA, and were not detectable in mild CAA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This is to our knowledge the first investigation of the link between CAA and R<jats:sub>2<\/jats:sub>, one of the major contrast mechanisms in MRI. R<jats:sub>2<\/jats:sub> is sensitive to CAA\u2010related brain abnormalities, primarily in moderate and severe stages of the disease. In\u00a0vivo detection of CAA is an important challenge, and the present work contributes new knowledge that may aid toward this goal.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.70037","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T08:24:53Z","timestamp":1746001493000},"page":"1214-1224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral Amyloid Angiopathy Is Associated With Higher <scp>R<sub>2<\/sub><\/scp> Relaxation Rate: An <scp>MRI<\/scp> and Pathology Study"],"prefix":"10.1002","volume":"12","author":[{"given":"Md Tahmid","family":"Yasar","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Illinois Institute of Technology  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold M.","family":"Evia","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical 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