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Clinical and MRI evaluations were performed in 38 pediatric MS patients and 13 healthy controls (HC). No significant differences in upper cervical cord area were found between MS patients and HC or between patients with and without lesions. Patients with lesions showed increased cord volume, co\u2010localizing with lesions, likely reflecting inflammation. Our results suggest that upper cord atrophy is not a prominent feature in early pediatric MS, underscoring the inflammation\u2010driven characteristic of these patients.<\/jats:p>","DOI":"10.1002\/acn3.70046","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T13:03:56Z","timestamp":1744895036000},"page":"1901-1906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Spinal Cord Abnormalities in Early Pediatric Multiple Sclerosis"],"prefix":"10.1002","volume":"12","author":[{"given":"Monica","family":"Margoni","sequence":"first","affiliation":[{"name":"Neuroimaging Research Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neurorehabilitation Unit IRCCS San Raffaele Scientific Institute  Milan 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