{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:48:23Z","timestamp":1791823703498,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J01788"],"award-info":[{"award-number":["2021J01788"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Transl Neurol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the reliability of very high\u2010frequency oscillations (VHFOs, 500\u20132000\u2009Hz) as biomarkers in identifying the epileptogenic zone (EZ) in mesial temporal lobe epilepsy (MTLE) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 19 MTLE patients who underwent stereo\u2010electroencephalography\u2010guided radiofrequency thermocoagulation. Interictal and ictal VHFOs were captured in four regions of interest (ROIs): amygdalohippocampal complex (AHC), parahippocampal gyrus (PG), white matter, and lateral temporal lobe. We analyzed the occurrence of VHFOs per minute, per contact: (a) in each ROI; (b) during awake resting state, sleep, and seizure within the seizure onset zone (SOZ) and non\u2010SOZ contacts; (c) in the EZ, propagation zone (PZ), and non\u2010involved zone (NIZ). The percentage and ratio of thermocoagulated VHFOs contacts in seizure\u2010free (SF) and non\u2010seizure\u2010free (NSF) patients were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the last follow\u2010up (19.31\u2009\u00b1\u20096.36\u2009months), 13 patients were SF and 6 were NSF. The VHFOs rate was significantly higher in the SOZ contacts during the ictal than interictal period compared to non\u2010SOZ contacts. Very\u2010fast ripples rate was more prevalent in the EZ than in the NIZ. VHFOs rate was higher in the AHC and PG compared to other regions. At a group level, SF patients had a higher percentage and ratio of thermocoagulated VHFOs contacts compared to NSF patients. At a patient level, some NSF patients had most of their VHFO\u2010generating tissues ablated, while some SF did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The presence and ablation of VHFO\u2010generating areas was associated with good surgical outcome at a group level. However, at a patient level, VHFOs may not be as reliable in identifying the EZ.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acn3.70050","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T07:26:06Z","timestamp":1744615566000},"page":"1151-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Very High\u2010Frequency Oscillations in Mesial Temporal Lobe Epilepsy: Identifying the Epileptogenic Zone"],"prefix":"10.1002","volume":"12","author":[{"given":"St\u00e9phane","family":"Jean","sequence":"first","affiliation":[{"name":"Pediatric Epilepsy Center Fujian Medical University Fuzhou Children's Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihai","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fujian Medical University Union Hospital  Fuzhou 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